I125 CYTO-TOXICITY - IMPLICATIONS FOR THERAPY AND ESTIMATION OF RADIATION RISK
I125 CYTO-TOXICITY - IMPLICATIONS FOR THERAPY AND ESTIMATION OF RADIATION RISK
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DOI：
10.1016/0047-0740(81)90071-1
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
ADELSTEIN, SJ
中科院分区：
文献类型：
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作者：
BLOOMER, WD;ADELSTEIN, SJ
The consequences of differential [vertebrate] subcellular radionuclide accumulation, particularly within nuclear structures, have important implications for the design and development of radiopharmaceuticals for [cancer] therapy and for the estimation of radiation risks. There is a growing body of experimental data demonstrating that localization of 125I within nuclear structures results in marked cytotoxicity. The physical and biological consequences of 125I decay when 125I is incorporated into cells as iododeoxyuridine or iodotamoxifen is reviewed.
