Methods of assessment of copper status in humans: a systematic review
Methods of assessment of copper status in humans: a systematic review
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DOI：
10.3945/ajcn.2009.27230e
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发表时间：
2009-06-01
影响因子：
7.1
通讯作者：
Fairweather-Tait, Susan J.
中科院分区：
文献类型：
--
作者：
Harvey, Linda J.;Ashton, Kate;Fairweather-Tait, Susan J.
背景资料：铜的膳食充足性的评估受到缺乏公认的铜状态生物标志物的限制。目的：目的是系统地回顾铜状态生物标志物的有用性，并确定那些反映状态变化超过>= 4 wk的生物标志物。设计：方法包括对奥维德MEDLINE、EMBASE（奥维德）和科克伦数据库进行结构化检索，检索日期为2007年10月，随后使用正式的纳入/排除标准，数据提取，有效性评估，和荟萃analysis.Results：共16项研究（288名参与者）被列入审查，与16个可能的铜生物标志物的数据。所有纳入的研究都是小型研究，偏倚风险高。血清铜的数据表明其作为生物标志物的价值，反映了在耗尽和充满个人的状态变化，虽然这些变化在后者较小。总铜蓝蛋白与铜状态有关，但仅反映高度耗竭个体的变化。红细胞超氧化物歧化酶和尿脱氧吡啶啉不是有用的生物标志物，但没有足够的数据得出关于血浆、红细胞和血小板铜;白细胞超氧化物歧化酶;红细胞、血小板和血浆谷胱甘肽过氧化物酶;血小板和白细胞细胞色素c氧化酶;总谷胱甘肽;二胺氧化酶和尿吡啶啉的确切结论。数据的缺乏，防止详细的亚组analysis.Conclusions：尽管数据有限，血清铜似乎是一个有用的生物标志物铜状态在人口水平。需要进一步进行低偏倚风险的大型研究，以探索其他铜状态生物标志物的有效性以及生物标志物反应性、剂量和补充时间之间的关系。美国临床营养杂志2009; 89（增刊）：2009 S-24 S。
Background: The assessment of dietary adequacy of copper is constrained by the absence of recognized copper status biomarkers.Objectives: The objectives were to systematically review the usefulness of copper status biomarkers and identify those that reflected changes in status over >= 4 wk.Design: The methods included a structured search on Ovid MEDLINE, EMBASE (Ovid), and Cochrane databases to October 2007, followed by the use of formal inclusion/exclusion criteria, data extraction, validity assessment, and meta-analysis.Results: A total of 16 studies (288 participants) were included in the review, with data on 16 possible copper biomarkers. All of the included studies were small and at high risk of bias. Data for serum copper suggested its value as a biomarker, reflecting changes in status in both depleted and replete individuals, although these changes were smaller in the latter. Total ceruloplasmin protein is related to copper status but reflects changes in highly depleted individuals only. Erythrocyte superoxide dismutase and urinary deoxypyridinoline are not useful biomarkers, but there were insufficient data to draw firm conclusions about plasma, erythrocyte, and platelet copper; leukocyte superoxide dismutase; erythrocyte, platelet, and plasma glutathione peroxidase; platelet and leukocyte cytochrome-c oxidase; total glutathione; diamine oxidase; and urinary pyridinoline. The paucity of data prevented detailed subgroup analysis.Conclusions: Despite limited data, serum copper appears to be a useful biomarker of copper status at the population level. Further large studies with low risk of bias are needed to explore the effectiveness of other biomarkers of copper status and the relation between biomarker responsiveness, dose, and period of supplementation. Am J Clin Nutr 2009; 89(suppl): 2009S-24S.