THE TRITHORAX-LIKE GENE ENCODES THE DROSOPHILA GAGA FACTOR
THE TRITHORAX-LIKE GENE ENCODES THE DROSOPHILA GAGA FACTOR
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DOI：
10.1038/371806a0
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发表时间：
1994-10-27
期刊：
影响因子：
64.8
通讯作者：
KARCH, F
中科院分区：
文献类型：
--
作者：
FARKAS, G;GAUSZ, J;KARCH, F
关于高阶染色质结构对基因表达和染色体拓扑结构的影响，人们知之甚少。对果蝇的遗传分析导致了两类基因的发现，即同源异型基因的调节者和位置效应变异的修饰者，它们似乎是编码某些染色质功能调节因子(1，2)的良好候选者。我们在这里描述的三胸类基因是同源异型基因正常表达所必需的，是位置效应变异的修饰物。我们发现Trithorax类编码GagA因子，GagA因子参与在启动子序列(3)上形成可接近的染色质结构。我们的遗传分析表明，GagA因子的染色质模拟功能并不局限于启动子区域。
LITTLE is known about the way higher-order chromatin structure influences gene expression and chromosome topology in general. Genetic analysis in Drosophila has led to the discovery of two classes of genes, the regulators of homeotic genes and the modifiers of position-effect variegation, which seem to be good candidates for encoding some of the factors regulating chromatin functions(1,2). The Trithorax-like gene we describe here is required for the normal expression of the homeotic genes and is a modifier of position-effect variegation. We found that Trithorax-like encodes the GAGA factor which is involved in the formation of an accessible chromatin structure at promoter sequences(3). Our genetic analysis suggests that the chromatin modelling function of the GAGA factor is not restricted to promoter regions.