Role of Th2 Cells in IgG4-Related Lacrimal Gland Enlargement
Role of Th2 Cells in IgG4-Related Lacrimal Gland Enlargement
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DOI：
10.1159/000312125
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发表时间：
2010-01-01
影响因子：
2.8
通讯作者：
Nakajima, Hiroshi
中科院分区：
文献类型：
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作者：
Kanari, Hiroko;Kagami, Shin-ichiro;Nakajima, Hiroshi
背景：泪腺增大(LGE)是Mikulicz病(MD)的特征之一。最近有报道称MD患者血清IgG4水平显著升高，外分泌腺内可见明显的IgG4阳性浆细胞浸润。然而，对CD4+T细胞及其细胞因子在IgG4相关疾病中的作用知之甚少。本研究旨在探讨IgG4相关疾病患者外周血中CD4+T细胞的特点。方法：对9例血清IgG4水平升高的LGE患者的临床特点进行分析。我们还检测了IgG4相关的LGE患者外周血中细胞因子和转录因子的mRNA表达。结果：所有与IgG4相关的LGE患者血清IgE水平均升高。此外，9例IgG4相关LGE患者中有5例出现嗜酸性粒细胞增多症和哮喘样症状。与正常对照组比较，IgG4相关性IgE患者外周血中IL-4、IL-5、IL-10和GATA-3的表达明显增强，而对干扰素-γ和T-bet的表达无明显影响。结论：Th2细胞可能参与了IgG4相关疾病的发病过程。版权所有(C)2010 S.Karger AG，巴塞尔
Background: Lacrimal gland enlargement (LGE) is one of the characteristics of Mikulicz's disease (MD). Recently, marked serum IgG4 elevation and infiltration of IgG4-positive plasmacytes in the enlarged exocrine glands have been reported in MD patients. However, little is known about the role of CD4+ T cells and their cytokines in IgG4-related diseases. The aim of this study was to evaluate the characteristics of CD4+ T cells in patients with IgG4-related diseases. Methods: We investigated the clinical characteristics of 9 patients with LGE and elevated serum IgG4 levels (named IgG4-related LGE). We also examined mRNA expression of cytokines and transcription factors of peripheral blood CD4+ T cells in patients with IgG4-related LGE. Results: All patients with IgG4-related LGE showed elevated serum IgE levels. In addition, 5 of 9 patients with IgG4-related LGE exhibited eosinophilia and asthma-like symptoms. In patients with IgG4-related LGE, mRNA expression of IL-4, IL-5, IL-10 and GATA-3 but not IFN-gamma or T-bet was enhanced on CD4+ T cells compared with that in healthy controls. Conclusions: Th2 cells may be involved in the pathogenesis of IgG4-related diseases. Copyright (C) 2010 S. Karger AG, Basel