PGC-1α:: a key regulator of energy metabolism
PGC-1α:: a key regulator of energy metabolism
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DOI：
10.1152/advan.00052.2006
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发表时间：
2006-12-01
影响因子：
2.1
通讯作者：
Ward, Walter F.
中科院分区：
文献类型：
--
作者：
Liang, Huiyun;Ward, Walter F.
过氧化物酶体增殖物激活受体-γ 共激活因子 (PGC)-1 α 是转录共激活因子家族的一员，在细胞能量代谢的调节中发挥着核心作用。它是由寒冷暴露强烈诱导的，将这种环境刺激与适应性产热联系起来。 PGC-1 α 刺激线粒体生物发生并促进肌肉组织重塑为纤维型组合物，该组合物在代谢上氧化性更强，糖酵解性更少，并且参与碳水化合物和脂质代谢的调节。 PGC-1 α 很可能与肥胖、糖尿病和心肌病等疾病密切相关。特别是，它在脂质代谢中的调节功能使其成为治疗肥胖和 2 型糖尿病的药物干预的诱人目标。
Peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1 alpha is a member of a family of transcription coactivators that plays a central role in the regulation of cellular energy metabolism. It is strongly induced by cold exposure, linking this environmental stimulus to adaptive thermogenesis. PGC-1 alpha stimulates mitochondrial biogenesis and promotes the remodeling of muscle tissue to a fiber-type composition that is metabolically more oxidative and less glycolytic in nature, and it participates in the regulation of both carbohydrate and lipid metabolism. It is highly likely that PGC-1 alpha is intimately involved in disorders such as obesity, diabetes, and cardiomyopathy. In particular, its regulatory function in lipid metabolism makes it an inviting target for pharmacological intervention in the treatment of obesity and Type 2 diabetes.