The utility of serum leptin and follicular fluid leptin, estradiol, and progesterone levels during an in vitro fertilization cycle
The utility of serum leptin and follicular fluid leptin, estradiol, and progesterone levels during an in vitro fertilization cycle
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DOI：
10.1007/s10815-007-9106-0
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发表时间：
2007-05-01
影响因子：
3.1
通讯作者：
Frattarelli, John L.
中科院分区：
文献类型：
--
作者：
Hill, Micah J.;Uyehara, Catherine F. T.;Frattarelli, John L.
目的：为了前瞻性地评估血清和卵泡液瘦素，雌二醇和孕酮水平在体外fertilization.Methods：前瞻性观察研究测量血清水平在六个点在IVF周期和卵泡液在retrieval.Results：血清瘦素和雌二醇水平都显着增加的个体患者在IVF刺激过程中。没有一个瘦素水平因妊娠结局而异。BMI与所有瘦素水平显著相关。妊娠组卵泡液雌二醇与血清雌二醇相关（r = 0.97，p < 0.01），非妊娠组卵泡液雌二醇与血清雌二醇无关（r =-0.15，p = 0.81）。瘦素水平在IVF周期中增加，并且根据母体BMI在患者之间变化，但与其他血清激素水平或妊娠结局无关。妊娠结局成功反映在卵泡液和血清雌二醇水平之间的关系，独立于瘦素水平。
Purpose: To prospectively evaluate serum and follicular fluid leptin, estradiol, and progesterone levels during in vitro fertilization.Methods: Prospective observational study measuring serum levels at six points during the IVF cycle and follicular fluid at the time of retrieval.Results: Serum leptin and estradiol levels both significantly increased for the individual patients during the IVF stimulation process. None of the leptin levels differed based on pregnancy outcome. BMI significantly correlated with all leptin levels. Follicular fluid estradiol correlated with serum estradiol only in pregnant patients (r = 0.97, p < 0.01) and was unrelated in non-pregnant patients (r = -0.15, p = 0.81).Conclusion: Serum and follicular leptin levels are highly correlated. Leptin levels increase during the IVF cycle and vary between patients based on maternal BMI, but do not correlate with other serum hormone levels or pregnancy outcome. Pregnancy outcome success was reflected in the relationship between follicular fluid and serum levels of estradiol, independent of leptin levels.