A novel drug delivery system obtained from hydrophobic modified amphiphilic polymers by Maillard reaction
A novel drug delivery system obtained from hydrophobic modified amphiphilic polymers by Maillard reaction
复制标题
通过美拉德反应从疏水改性两亲性聚合物获得的新型药物递送系统
DOI：
10.1016/j.ijbiomac.2020.04.218
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发表时间：
2020-08-15
影响因子：
8.2
通讯作者：
Wu, Qian
中科院分区：
文献类型：
--
作者：
Feng, Nianjie;Wu, Hua;Wu, Qian
为了提高生物利用度，首次以热水预处理液中的半纤维素组分为原料，通过美拉德反应设计了新型两亲性聚合物。对两亲性聚合物的结构特征、乳化性能和药物释放行为进行了详细的研究。结果表明，半纤维素组分与十二胺反应可得到取代度为0.31 ~ 1.65的两亲性聚合物。并成功制备了紫杉醇纳米载体。两亲聚合物提供了优异的乳化性能和所需的储存稳定性。乳液的平均粒径保持在235-266 nm的范围内，甚至在储存90天后。此外，两亲性聚合物还表现出相当的紫杉醇保存能力和pH响应性释放性能。紫杉醇在pH5.0时有较好的控释效果，可作为疏水性药物的缓释载体。(C)2018爱思唯尔B. V.保留所有权利。
In order to improve the bioavailability of paditaxel, hemicellulose fractions from hot water pretreatment liquor were the first time to design new amphiphilic polymers through the Maillard reaction. Structural characteristics, emulsifying and drug release behaviors of the amphiphilic polymers were then investigated in detail. Results showed that the amphiphilic polymers with degrees of substitution ranging from 0.31 to 1.65 were obtained by reacting hemicellulose fractions with dodecylamine. Furthermore, the nanometer paclitaxel emusion was successfully preparaed. The amphiphilic polymer provided excellent emulsifying properties and desired storage stability. The average particle sizes of emulsion stayed in the range of 235-266 nm, even after 90 days of storage. Besides, the amphiphilic polymer also proved considerable paclitaxel preservation ability and released performance of pH-responsive. The controlled release of paclitaxel was better at pH 5.0, and thus the new amphiphilic polymer can be used as a delivery carrier of hydrophobic drugs. (C) 2018 Elsevier B.V. All rights reserved.