Effects of Age and Sex on the Concentrations of Glutamate and Glutamine in the Human Brain
Effects of Age and Sex on the Concentrations of Glutamate and Glutamine in the Human Brain
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DOI：
10.1002/jmri.24123
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发表时间：
2013-12-01
影响因子：
4.4
通讯作者：
Schubert, Florian
中科院分区：
文献类型：
--
作者：
Haedel, Sven;Wirth, Christoph;Schubert, Florian
目的采用专门的测量和评价程序，确定年龄和性别对健康人大样本脑谷氨酸和谷氨酰胺浓度的影响。对118名19 ~ 55岁健康人的脑代谢产物进行了探索性研究（59只雌性）谷氨酸、谷氨酰胺、N-乙酰天冬氨酸（NAA）、总肌酸，和总胆碱（tCho）的体素，包括左海马（HC）和前扣带皮层（ACC）进行了研究，使用点-在3特斯拉下具有80 ms回波时间的分辨光谱学结合可靠的定量程序。特别注意采取纠正多重comparation. ResultsA年龄相关的谷氨酸在这两个地区的浓度下降的研究，而谷氨酰胺水平ACC随着年龄的增长。统计学上显着的性别相关的差异检测谷氨酸在HC和tCho在ACC. NAA随着年龄的增长在这两个区域，的意义不生存Bonferroni correction.ConclusionThe结果表明年龄和性别的影响谷氨酸，谷氨酰胺，胆碱含化合物，和NAA在健康的人脑。他们增加了越来越多的证据，证明大脑神经传递，代谢和结构在整个生命周期中存在性别特异性差异。
PurposeTo determine the effects of age and sex on cerebral glutamate and glutamine concentrations in a large sample of healthy humans using a dedicated measuring and evaluation procedure. Exploratory examinations of other brain metabolites were also conducted.Materials and MethodsIn 118 healthy subjects aged 19 to 55 years (59 female) absolute concentrations of glutamate, glutamine, N-acetylaspartate (NAA), total creatine, and total choline (tCho) in voxels comprising the left hippocampus (HC) and the anterior cingulate cortex (ACC) were investigated using point-resolved spectroscopy with an echo time of 80 ms at 3 Tesla in combination with a reliable quantification procedure. Special care was taken to correct for multiple comparisons.ResultsAn age-related decline of the concentrations of glutamate in both regions studied was observed whereas glutamine levels in ACC increased with age. Statistically significant sex-related differences were detected for glutamate in the HC and for tCho in the ACC. NAA decreased with age in both regions, the significance not surviving Bonferroni correction.ConclusionThe results demonstrate effects of age and gender on glutamate, glutamine, choline containing compounds, and NAA in healthy human brain. They add to the growing evidence for gender-specific differences in cerebral neurotransmission, metabolism, and structure across the lifespan.