Tripartite motif-containing 29 as a novel biomarker in non-small cell lung cancer
Tripartite motif-containing 29 as a novel biomarker in non-small cell lung cancer
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DOI：
10.3892/ol.2015.3623
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发表时间：
2015-10-01
期刊：
影响因子：
2.9
通讯作者：
Zhang, Jiandong
中科院分区：
文献类型：
--
作者：
Song, Xiaoming;Fu, Chunhai;Zhang, Jiandong
含三方基序29(TRIM29)是三方基序(TRIM)蛋白家族的一员。据报道，TRIM29在许多癌症类型中被解除调控，提示TRIM29具有致癌作用。然而，其在非小细胞肺癌(NSCLC)中的临床意义尚未完全阐明。在本研究中，通过免疫组织化学方法研究了2000年至2007年间320例手术切除的非小细胞肺癌患者石蜡标本中TRIM29的表达状况。TRIM29的高表达与吸烟(P=0.012)、T分期(P=0.015)和M分期(P=0.003)显著相关。此外，TRIM29表达水平的升高与总体(OS)和无病生存率的降低相关。此外，TRIM29的高表达是OS的独立预后因素[P=0.003，危险比(HR)=2.102，95%可信区间(CI)1.069-3.193]。综上所述，这些结果提示TRIM29可能是一个有用的非小细胞肺癌患者预后标志物和潜在的治疗非小细胞肺癌的分子靶点。
Tripartite motif-containing 29 (TRIM29) is a member of the tripartite motif (TRIM) protein family. TRIM29 has been reported to be deregulated in a number of cancer types, suggesting the oncogenic function of TRIM29. However, its clinical significance in non-small cell lung cancer (NSCLC) has not been fully elucidated. In the present study, the TRIM29 expression status was investigated by immunohistochemical analysis in paraffin-embedded specimens obtained from 320 patients with surgically resected NSCLC, treated between 2000 and 2007. High TRIM29 expression was significantly associated with smoking (P=0.012), T stage (P=0.015) and M stage (P=0.003). Furthermore, elevated TRIM29 expression level was correlated with reduced overall (OS) and disease-free survival. In addition, high TRIM29 expression was an independent prognostic factor for OS [P=0.003, hazard ratio (HR)=2.102, 95% confidence interval (CI), 1.069-3.193]. In conclusion, these results suggest that TRIM29 may be a useful prognostic marker in NSCLC patients and a potential molecular target for NSCLC treatment.