INCIDENCE OF DYSPLASIA AND CARCINOMA OF THE UTERINE CERVIX IN AN APPALACHIAN POPULATION
INCIDENCE OF DYSPLASIA AND CARCINOMA OF THE UTERINE CERVIX IN AN APPALACHIAN POPULATION
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DOI：
10.1093/jnci/84.13.1030
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发表时间：
1992-07-01
期刊：
影响因子：
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通讯作者：
NADEL, M
中科院分区：
文献类型：
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作者：
FRIEDELL, GH;TUCKER, TC;NADEL, M
背景：肯塔基州东南部阿巴拉契亚地区人口的宫颈癌死亡率已被证明异常高。为了更好地了解该地区宫颈癌的高死亡率，我们开发了基于人群的宫颈疾病登记系统。目的：本研究根据组织学诊断描述了 1986 年和 1987 年肯塔基州阿巴拉契亚山脉 36 个县地区白人妇女中宫颈发育不良、原位癌和浸润性宫颈癌的发病率。方法：我们将研究区域的原位癌和浸润性宫颈癌的年平均年龄调整发病率与监测、流行病学和最终结果 (SEER) 计划中的女性进行了比较。结果：研究地区女性浸润性宫颈癌的发病率（14.9/10万）几乎是SEER人群中白人女性（7.8/10万）的两倍，但与SEER人群中黑人女性（15.3/10万）相似。研究人群中女性原位癌的发病率（每 10 万人 38.2 人）比 SEER 人群中白人女性（每 10 万人 31.5 人）或黑人女性（每 10 万人 31.2 人）高 21%。研究人群中女性所有级别不典型增生的年平均发病率为每 10 万人 194.6 例。无法确定基于人群的可比较的不典型增生发病率。结论：阿巴拉契亚肯塔基州的宫颈癌发病率高于 SEER 人群。贫困似乎是与这些比率相关的一个因素。影响：低密度人口，例如阿巴拉契亚农村地区的人口，在癌症控制研究中值得更多关注。这里报告的基于人群的宫颈发育不良率可能有助于未来调查的比较。
Background: Cervical cancer mortality rates in the Appalachian population of southeastern Kentucky have been shown to be unusually high. To better understand the high cervical cancer death rate in this area, we developed a population-based cervical disease registry. Purpose: This study describes the incidence of cervical dysplasia, carcinoma in situ, and invasive cervical cancer in 1986 and 1987 among White women in a 36-county area of Appalachian Kentucky based on histologic diagnoses. Methods: We compared average annual age-adjusted incidence rates for carcinoma in situ and invasive cervical cancer in the study area with those for women in the Surveillance, Epidemiology, and End Results (SEER) Program. Results: The incidence rate of invasive cervical cancer for women in the study area (14.9 per 100 000) was nearly twice that for White women in the SEER population (7.8 per 100 000), but it was similar to that for Black women in the SEER population (15.3 per 100 000). The incidence of carcinoma in situ for women in the study population (38.2 per 100 000) was 21% higher than that for White women (31.5 per 100 000) or for Black women (31.2 per 100 000) in the SEER population. The average annual age-adjusted incidence rate for all grades of dysplasia among women in the study population was 194.6 per 100 000. No comparable population-based incidence rates for dysplasia could be identified. Conclusions: Cervical cancer incidence rates are higher in Appalachian Kentucky than in the SEER population. Poverty appears to be a factor associated with these rates. Implications: Low-density populations such as those in rural Appalachia deserve greater attention in cancer control research. The population-based cervical dysplasia rates reported here may be useful for comparisons in future investigations.