The changes of serotonin-modulating anticonsolidation protein and dihydropyrimidinase-related protein 2 in the amygdala and blood of depressive rats
The changes of serotonin-modulating anticonsolidation protein and dihydropyrimidinase-related protein 2 in the amygdala and blood of depressive rats
复制标题
抑郁大鼠杏仁核和血液中血清素调节抗巩固蛋白和二氢嘧啶酶相关蛋白2的变化
DOI：
10.59883/ajp.37
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
L. F. Hasanova
中科院分区：
文献类型：
--
作者：
L. F. Hasanova
如今，抑郁症被指精神疾病，并在世界各地广泛传播。人类抑郁症的发病机制以脑结构中5-羟色胺代谢的显著紊乱及其下调为特征。本研究的目的是明确抑郁Wistar大鼠杏仁核、血小板中5-羟色胺调节的抗巩固蛋白(SMAP)和二氢嘧啶酶相关蛋白2(DRP2)的水平，以及抗SMAP的天然自身抗体。优势模型大鼠形成抑郁状态，在强迫游泳实验中，主动游泳时间缩短，证实其形成成功。通过对抑郁雄性和雌性大鼠的间接ELISA试验，观察到抑郁雄性大鼠杏仁核SMAP和DRP2表达下调，抑郁雄性大鼠血小板SMAP表达上调，雌性抑郁大鼠血小板DRP2表达显著下调，抑郁雄性大鼠血清中抗SMAP天然自身抗体显著降低。
Nowadays, depression is referred to psychiatric disease and is widely spread throughout the world. The pathogenesis of depression in humans is characterized by significant disturbances of serotonin turnover and its downregulation in brain structures. The objective of the present study was the definition of the levels of serotonin-modulating anticonsolidation protein (SMAP) and dihydropyrimidinase-related protein 2 (DRP2) in the brain amygdala, platelets, and to anti-SMAP natural autoantibodies in the depression Wistar rats of both sexes. A depression state in the rats was formed in the dominant model and its successful formation was confirmed in the forced swimming test by the decreased timeframe of active swimming. Through the application of an indirect ELISA test in the depressive male and female rats, a downregulation of SMAP and DRP2 in the amygdala, an upregulation of SMAP in the platelets of depressive male rats, a noticeable downregulation of DRP2 in the platelets of depressive female rats, and a sharp downregulation of anti-SMAP natural autoantibodies in the serum of depressive male rats were observed.