Soluble Interleukin-2 Receptor Level at Diagnosis Predicts Prognosis of Patients With Follicular Lymphoma Irrespective of Initial Management Strategy
Soluble Interleukin-2 Receptor Level at Diagnosis Predicts Prognosis of Patients With Follicular Lymphoma Irrespective of Initial Management Strategy
复制标题
无论初始治疗策略如何，诊断时可溶性白细胞介素 2 受体水平均可预测滤泡性淋巴瘤患者的预后
DOI：
10.21873/anticanres.13706
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发表时间：
2019
影响因子：
2
通讯作者：
O. Miura
中科院分区：
文献类型：
--
作者：
Masahide Yamamoto;Keisuke Tanaka;Yoshihiro Umezawa;Toshikage Nagao;S. Toyota;O. Miura
背景/目的：虽然滤泡性淋巴瘤（FL）的各种预后指标已被提出，他们是专为需要立即治疗的患者。我们的目的是开发一种新的简单的预后工具，适用于所有患者的FL在诊断。材料与方法：我们回顾性分析了来自两个中心的140例FL患者的各种临床、病理和实验室数据，包括可溶性白细胞介素2受体（sIL 2 R）对预后的影响。本研究分析了可溶性白细胞介素2受体（sIL 2 R）的影响，以开发一种新的简单的预后工具，适用于所有患者的FL在诊断。结果：这些患者的初始管理是观察等待（n=48）或立即治疗（n=92）。24个月时的无事件生存率可预测总生存率。当根据诊断时的sIL 2 R水平分为三组时，非常高的sIL 2 R水平确定了约20%的患者与其他患者相比生存率明显较差。结论：sIL 2 R是一种非常有效的生物标志物，可以很容易地应用于常规实践中，以预测所有FL患者在诊断时的生存率，无论最初的治疗方法如何。
Background/Aim: Although various prognostic indices for follicular lymphoma (FL) have been proposed, they are designed specifically for patients requiring immediate therapy. We aimed to develop a new simple prognostic tool applicable for all patients with FL at diagnosis. Materials and Methods: We retrospectively analyzed various clinical, pathological, and laboratory data, including soluble interleukin-2 receptor (sIL2R), from 140 patients with FL from two centers for their impact on prognosis. This study analyzed the impact of soluble interleukin-2 receptor (sIL2R) in order to develop a new simple prognostic tool applicable for all patients with FL at diagnosis. Results: The initial management of these patients was watchful waiting (n=48) or immediate treatment (n=92). Event-free survival at 24 months predicted overall survival. When categorized into three groups according to the sIL2R levels at diagnosis, a very high sIL2R level identified about 20% of patients with a distinctively worse survival compared to the others. Conclusion: sIL2R is a very effective biomarker that can be easily applied in routine practice to predict survival for all patients with FL at diagnosis irrespective of initial management approach.
影响因子：
45.3
作者：
Casulo, Carla;Byrtek, Michelle;Friedberg, Jonathan W.
通讯作者：
Friedberg, Jonathan W.