Inducing your neighbors to become like you: cell recruitment in developmental patterning and growth
Inducing your neighbors to become like you: cell recruitment in developmental patterning and growth
复制标题
DOI：
10.1387/ijdb.200127mn
复制
发表时间：
2021-01-01
影响因子：
0.7
通讯作者：
Nahmad, Marcos
中科院分区：
文献类型：
--
作者：
Manuel Munoz-Nava, Luis;Flores-Flores, Marycruz;Nahmad, Marcos
Cell differentiation, proliferation, and morphogenesis are generally driven by instructive signals that are sent and interpreted by adjacent tissues, a process known as induction. Cell recruitment is a particular case of induction in which differentiated cells produce a signal that drives adjacent cells to differentiate into the same type as the inducers. Once recruited, these new cells may become inducers to continue the recruitment process, closing a feed-forward loop that propagates the growth of a specific cell-type population. So far, little attention has been given to cell recruitment as a developmental mechanism. Here, we review the components of cell recruitment and discuss its contribution to development in three different examples: the Drosophila wing, the vertebrate inner ear, and the mammalian thyroid gland. Finally, we posit some open questions about the role of cell recruitment in organ patterning and growth.
