The role of mitochondria in yeast programmed cell death.
The role of mitochondria in yeast programmed cell death.
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DOI：
10.3389/fonc.2012.00070
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发表时间：
2012
影响因子：
4.7
通讯作者：
Giannattasio S
中科院分区：
文献类型：
--
作者：
Guaragnella N;Zdralević M;Antonacci L;Passarella S;Marra E;Giannattasio S
哺乳动物细胞凋亡和酵母细胞程序性死亡（PCD）有许多共同的特征，包括活性氧的产生、蛋白酶活性和线粒体的重要作用。鉴于此，以及区分酵母和多细胞生物PCD的独特特征，线粒体对遗传上易处理的酵母酿酒酵母（Saccharomyces cerevisiae）中细胞死亡的贡献已被深入研究。在这个小型审查中，我们报告是否以及如何酵母线粒体功能和蛋白属于氧化磷酸化，蛋白质贩运进出线粒体，和线粒体动力学，在PCD中发挥作用。由于在PCD的许多过程发生随着时间的推移，重点将放在实验模型的基础上乙酸诱导的PCD（AA-PCD），它具有独特的功能，已被调查作为时间的函数。如将描述的，存在至少两种AA-PCD途径，每种途径具有由线粒体组分，特别是细胞色素c发挥的多方面作用。
Mammalian apoptosis and yeast programmed cell death (PCD) share a variety of features including reactive oxygen species production, protease activity and a major role played by mitochondria. In view of this, and of the distinctive characteristics differentiating yeast and multicellular organism PCD, the mitochondrial contribution to cell death in the genetically tractable yeast Saccharomyces cerevisiae has been intensively investigated. In this mini-review we report whether and how yeast mitochondrial function and proteins belonging to oxidative phosphorylation, protein trafficking into and out of mitochondria, and mitochondrial dynamics, play a role in PCD. Since in PCD many processes take place over time, emphasis will be placed on an experimental model based on acetic acid-induced PCD (AA-PCD) which has the unique feature of having been investigated as a function of time. As will be described there are at least two AA-PCD pathways each with a multifaceted role played by mitochondrial components, in particular by cytochrome c.