Dissociating top-down attentional control from selective perception and action
Dissociating top-down attentional control from selective perception and action
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DOI：
10.1016/s0028-3932(01)00117-8
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发表时间：
2001-01-01
期刊：
影响因子：
2.6
通讯作者：
Mangun, GR
中科院分区：
文献类型：
--
作者：
Hopfinger, JB;Woldorff, MG;Mangun, GR
对注意力的神经机制的研究已经揭示了一个复杂的大脑区域网络，它与执行需要注意力的任务有关。人类神经成像的最新进展现在允许对大脑注意系统的特定组成部分所提供的基本注意过程进行调查。本文描述了近年来利用正电子发射断层扫描（PET）、功能性磁共振成像（fMRI）和事件相关脑电位（ERPs）研究空间选择性注意相关神经活动的时空动态的研究。我们首先回顾了事件相关fMRI研究的结果，该研究检查了自上而下的注意控制与选择性感觉知觉的神经机制。这些结果定义了一个参与控制空间注意力的额-颞-顶叶网络。这些区域的活动偏向于编码即将到来的目标刺激的空间位置的感觉脑结构的神经活动，在视觉皮层随后的目标处理的调节之前。然后，我们从空间注意的快速事件相关fMRI研究中提供了初步证据，该研究展示了如何在注意控制研究中解开由时间相邻刺激引起的潜在重叠血流动力学反应。最后，我们介绍了神经成像（PET）和事件相关脑电位（ERP）联合研究的新分析，这些研究共同揭示了与注意力控制和选择性感知有关的大脑区域的激活时间过程。2001爱思唯尔科学有限公司版权所有。
Research into the neural mechanisms of attention has revealed a complex network of brain regions that are involved in the execution of attention-demanding tasks. Recent advances in human neuroimaging now permit investigation of the elementary processes of attention being subserved by specific components of the brain's attention system. Here we describe recent studies of spatial selective attention that made use of positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and event-related brain potentials (ERPs) to investigate the spatio-temporal dynamics of the attention-related neural activity. We first review the results from an event-related fMRI study that examined the neural mechanisms underlying top-down attentional control versus selective sensory perception. These results defined a fronto-temporal-parietal network involved in the control of spatial attention. Activity in these areas biased the neural activity in sensory brain structures coding the spatial locations of upcoming target stimuli, preceding a modulation of subsequent target processing in visual cortex. We then present preliminary evidence from a fast-rate event-related fMRI study of spatial attention that demonstrates how to disentangle the potentially overlapping hemodynamic responses elicited by temporally adjacent stimuli in studies of attentional control. Finally, we present new analyses from combined neuroimaging (PET) and event-related brain potential (ERP) studies that together reveal the timecourse of activation of brain regions implicated in attentional control and selective perception. (C) 2001 Elsevier Science Ltd. All rights reserved.