Identification and analytical properties of acetyl fentanyl metabolites
Identification and analytical properties of acetyl fentanyl metabolites
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DOI：
10.1134/s1061934815020124
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发表时间：
2015-02-01
影响因子：
1.1
通讯作者：
Dvorskaya, O. N.
中科院分区：
文献类型：
--
作者：
Melent'ev, A. B.;Kataev, S. S.;Dvorskaya, O. N.
乙酰芬太尼是一种新型设计药物，是芬太尼的衍生物。使用气相色谱法和高效液相色谱质谱法检测乙酰芬太尼消费者的尿液样本，鉴定其主要代谢物。代谢物的结构被提出并通过电子冲击和大气压化学电离的破碎来证实。测定了乙酰芬太尼代谢物衍生物的质谱和色谱性质。乙酰芬太尼生物转化的主要途径是分子中苯乙基部分的羟基化。
Acetyl fentanyl is a novel designer drug substance, a derivative of fentanyl. Its major metabolites were identified in samples of urine from consumers of acetyl fentanyl using gas chromatography and high-performance liquid chromatography with mass spectrometry detection. Structures of metabolites were proposed and confirmed by their fragmentation on electron impact and atmospheric pressure chemical ionization. The mass spectral and chromatographic properties of some derivatives of acetyl fentanyl metabolites were determined. The main path of the biotransformation of acetyl fentanyl is the hydroxylation of the phenylethyl moiety in the molecule.