Diffusion-weighted and magnetization transfer imaging of the corpus callosum in Alzheimer's disease
Diffusion-weighted and magnetization transfer imaging of the corpus callosum in Alzheimer's disease
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DOI：
10.1016/s0022-510x(99)00135-5
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发表时间：
1999-08-01
影响因子：
4.4
通讯作者：
Abe, K
中科院分区：
文献类型：
--
作者：
Hanyu, H;Asano, T;Abe, K
我们利用矢状面弥散加权成像（DW）和磁化转移成像（MT）研究了阿尔茨海默病（AD）患者胼胝体的结构变化。AD患者（n=23）只有胼胝体后部的面积明显减少。AD患者在无明显萎缩的胼胝体前部和有明显萎缩的后部，垂直于互神经纤维方向的表观扩散系数（ADC）值明显高于对照组（n=16），因此患者在这些区域的扩散程度明显低于对照组（n=16）。AD患者胼胝体前部和后部的MT比率也明显低于对照组。这些发现可能反映了胼胝体的结构变化，包括轴突丢失和/或脱髓鞘。DW和MT图像可能有助于检测AD患者的胼胝体变性。(C) 1999 Elsevier Science B.V.版权所有
We investigated structural changes of the corpus callosum in patients with Alzheimer's disease (AD) using sagittal diffusion-weighted (DW) and magnetization transfer (MT) imaging. Patients with AD (n=23) had a significantly decreased area only in the posterior portion of the corpus callosum. Apparent diffusion coefficient (ADC) values perpendicular to the commisural fiber orientation were significantly higher in the anterior portion of the corpus callosum without definite atrophy, as well as in the posterior portion with significant atrophy, in patients with AD than in controls (n=16) and thus diffusion in these regions showed a significantly lower degree of anisotropy in patients than in controls. MT ratios were also significantly lower in patients with AD in the anterior and posterior portions of the corpus callosum than in controls. These findings probably reflect structural changes in the corpus callosum including axonal loss and/or demyelination. DW and MT imagings may be useful in detecting degeneration of the corpus callosum in AD. (C) 1999 Elsevier Science B.V. All rights reserved.