Contribution of Kv7.4/Kv7.5 Heteromers to Intrinsic and Calcitonin Gene-Related Peptide-Induced Cerebral Reactivity
Contribution of Kv7.4/Kv7.5 Heteromers to Intrinsic and Calcitonin Gene-Related Peptide-Induced Cerebral Reactivity
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DOI：
10.1161/atvbaha.114.303405
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发表时间：
2014-04-01
影响因子：
8.7
通讯作者：
Greenwood, Iain A.
中科院分区：
文献类型：
--
作者：
Chadha, Preet S.;Jepps, Thomas A.;Greenwood, Iain A.
目的大脑中动脉（MCA）的直径受固有的肌源性活性和强血管扩张剂如降钙素基因相关肽（CGRP）的影响。以前的研究表明，MCA表达KCNQ1，4和5钾通道基因，表达产物（Kv7通道）参与MCA直径的肌源性控制。本研究探讨了Kv7.4和Kv7.5亚型对MCA直径的肌源性和CGRP调节的作用，并确定了它们在高血压动物中是否受到影响。方法和结果在正常血压大鼠MCA上进行的等长张力记录产生CGRP血管舒张作用，该作用可被泛Kv7通道阻断剂linopirdine抑制（P
Objective Middle cerebral artery (MCA) diameter is regulated by inherent myogenic activity and the effect of potent vasodilators such as calcitonin gene-related peptide (CGRP). Previous studies showed that MCAs express KCNQ1, 4, and 5 potassium channel genes, and the expression products (Kv7 channels) participate in the myogenic control of MCA diameter. The present study investigated the contribution of Kv7.4 and Kv7.5 isoforms to myogenic and CGRP regulation of MCA diameter and determined whether they were affected in hypertensive animals.Approach and Results Isometric tension recordings performed on MCA from normotensive rats produced CGRP vasodilations that were inhibited by the pan-Kv7 channel blocker linopirdine (P