Eph proteins and the assembly of auditory circuits
Eph proteins and the assembly of auditory circuits
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DOI：
10.1016/j.heares.2004.11.024
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发表时间：
2005-08-01
期刊：
影响因子：
2.8
通讯作者：
Cramer, KS
中科院分区：
文献类型：
--
作者：
Cramer, KS
到达耳蜗中的听觉感受器细胞的声学信号中携带有多种信息。对这些信息的分析在很大程度上是可能的，因为听觉系统的神经元结构。建立听觉处理基础的精确回路的机制尚未确定。Eph受体酪氨酸激酶及其配体是调节轴突导向的蛋白质，并已显示有助于在神经系统的几个区域中建立拓扑投影。一些研究已经开始调查这些蛋白质是否参与听觉系统连接的形成。基因表达的研究表明，Eph蛋白广泛表达于内耳的结构以及听觉系统的外周和中枢成分的神经元中。功能研究表明，Eph信号影响听觉通路的组装。这些研究表明，Eph蛋白信号传导在听觉回路的形成中具有重要作用。(c)2005 Elsevier B.V.保留所有权利。
Many kinds of information are carried in the acoustic signal that reaches auditory receptor cells in the cochlea. The analysis of this information is possible in large part because of the neuronal architecture of the auditory system. The mechanisms that establish the precise circuitry that underlies auditory processing have not yet been identified. The Eph receptor tyrosine kinases and their ligands are proteins that regulate axon guidance and have been shown to contribute to the establishment of topographic projections in several areas of the nervous system. Several studies have begun to investigate whether these proteins are involved in the formation of auditory system connections. Studies of gene expression show that Eph proteins are extensively expressed in structures of the inner ear as well as in neurons in the peripheral and central components of the auditory system. Functional studies have demonstrated that Eph signaling influences the assembly of auditory pathways. These studies suggest that Eph protein signaling has a significant role in the formation of auditory circuitry. (c) 2005 Elsevier B.V. All rights reserved.