Lack of bronchomotor response to up to 3 ppm formaldehyde in subjects with asthma.
Lack of bronchomotor response to up to 3 ppm formaldehyde in subjects with asthma.
复制标题
哮喘患者对高达 3 ppm 的甲醛缺乏支气管运动反应。
DOI：
10.1016/0013-9351(84)90120-8
复制
发表时间：
1984
影响因子：
8.3
通讯作者：
Epstein,J
中科院分区：
文献类型：
--
作者：
Sheppard,D;Eschenbacher,WL;Epstein,J
进行了一项研究，以确定暴露于污染的室内空气中偶尔遇到的甲醛浓度是否会引起轻度哮喘受试者的支气管收缩。在7名受试者中，吸入1ppm甲醛10分钟引起的比气道阻力（SRaw）增加与吸入无甲醛空气引起的反应进行了比较。此外，增加SRaw引起的吸入1和3 ppm的甲醛在中度运动10分钟，与吸入甲醛自由空气在运动10分钟引起的反应进行了比较。吸入甲醛在休息和运动过程中没有引起显着增加SRaw在受试者。它的结论是，短暂暴露于这些浓度的甲醛，即使与适度的运动，本身是不太可能引起显着的支气管收缩，在大多数轻度哮喘患者。
A study was undertaken to determine whether exposure to concentrations of formaldehyde occasionally encountered in polluted indoor air would cause bronchoconstriction in subjects with mild asthma. In seven subjects the increase in specific airways resistance (SRaw) caused by inhalation of 1 ppm formaldehyde for 10 min was compared with the response caused by inhalation of formaldehyde-free air. Also, the increase in SRawcaused by inhalation of 1 and 3 ppm formaldehyde during moderate exercise for 10 min was compared with the response caused by inhalation of formaldehyde-free air during exercise for 10 min. Inhalation of formaldehyde at rest and during exercise did not cause a significant increase in SRawin the subjects. It is concluded that brief exposure to these concentrations of formaldehyde, even in association with moderate exercise, is unlikely by itself to cause significant bronchoconstriction in most subjects with mild asthma.