Novel approaches to the treatment of bacterial biofilm infections
Novel approaches to the treatment of bacterial biofilm infections
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DOI：
10.1111/bph.13706
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发表时间：
2017-07-01
影响因子：
7.3
通讯作者：
Webber, Mark A.
中科院分区：
文献类型：
--
作者：
Hughes, Gareth;Webber, Mark A.
细菌感染仍然是医疗保健的一个重大挑战，并导致严重的发病率和死亡率。由于人口老龄化和易感性的日益增加以及大量细菌分离株对抗生素产生了耐药性，这种情况变得更加复杂。形成生物膜并定植或感染医疗设备或伤口的细菌特别难以治疗，因为生物膜本质上具有高度的抗生素耐药性。大多数感染都有细菌以生物膜形式存在的成分，因此，预防或治疗生物膜相关感染非常重要。许多杀死生物膜的新策略正在开发中；这些包括弱有机酸的使用、光照射和噬菌体的应用。所有这些都有希望并且能够有效地杀死模型系统中的生物膜，但对于每一个来说仍然存在悬而未决的问题。这篇综述总结了生物膜感染的主要特征、每种新方法以及在将这些潜在治疗方法纳入临床使用之前仍然缺乏的证据。
Bacterial infection remains a major challenge to healthcare and is responsible for significant morbidity and mortality. This situation is becoming complicated by an increasingly ageing and susceptible population and large numbers of bacterial isolates, which have developed resistance to antibiotics. Bacteria that form biofilms and colonize or infect medical devices or wounds are particularly hard to treat as biofilms are inherently highly antibiotic resistant. Most infections have a component where bacteria exist as a biofilm and as a result, prevention or treatment of biofilm-associated infections is highly important. A number of novel strategies to kill biofilms have been in development; these include the use of weak organic acids, photo irradiation and the application of bacteriophage. All have promise and are able to effectively kill biofilms in model systems, but for each there are still unanswered questions. This review summarizes the main features of biofilm infections, each of these novel approaches and the evidence that is still lacking before these potential treatments can be incorporated into clinical usage.