Cytoskeletal transition at the paranodes: the Achilles' heel of myelinated axons.
Cytoskeletal transition at the paranodes: the Achilles' heel of myelinated axons.
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DOI：
10.1017/s1740925x07000415
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发表时间：
2007-05
影响因子：
--
通讯作者：
A. D. Sousa;M. Bhat
中科院分区：
文献类型：
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作者：
A. D. Sousa;M. Bhat
髓鞘形成将轴突组织成不同的区域，使神经冲动以跳跃式方式传播。髓鞘的边缘被轴突神经胶质连接所封闭，这种连接在组织轴突细胞骨架中起着至关重要的作用。在这里，我们提出了一个模型，在这个模型中，有髓鞘的轴突依赖于轴突-胶质连接来稳定偏执狂的细胞骨架转变。因此，旁腺区可能特别容易受到脱髓鞘疾病（如多发性硬化症）引起的损害。
Myelination organizes axons into distinct domains that allow nerve impulses to propagate in a saltatory manner. The edges of the myelin sheath are sealed at the paranodes by axon-glial junctions that have a crucial role in organizing the axonal cytoskeleton. Here we propose a model in which the myelinated axons depend on the axon-glial junctions to stabilize the cytoskeletal transition at the paranodes. Thus paranodal regions are likely to be particularly susceptible to damage induced by demyelinating diseases such as multiple sclerosis.