Expression of the lymphotoxin β receptor on follicular stromal cells in human lymphoid tissues
Expression of the lymphotoxin β receptor on follicular stromal cells in human lymphoid tissues
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DOI：
10.1038/sj.cdd.4400374
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发表时间：
1998-06-01
影响因子：
12.4
通讯作者：
Epstein, LB
中科院分区：
文献类型：
--
作者：
Murphy, M;Walter, BN;Epstein, LB
淋巴毒素 β 受体 (LT beta R) 及其配体 LT α 1 β 2 已被认为在淋巴组织的发育和组织中发挥关键作用。 LT beta R 在多种人类原代细胞和转化细胞上表达，但在 T 或 B 淋巴细胞以及原代单核细胞或外周树突细胞上明显缺失，尽管在一些髓系白血病细胞系中检测到 LT beta R。在发育中的胸腺中，LTβR 沿小梁突出并进入髓质直至皮质髓质交界处。在脾脏中，LTβR 主要由红髓中的细胞以及沿着与网状基质细胞共定位的红髓和白髓边界的细胞表达。 LT beta R 在人滤泡树突细胞系 FDC-1 上表达，当与 LT alpha 1 beta 2 复合物连接时，发出 CD54 表达信号。这些结果支持这样的概念：携带 LT α 1 β 2 的淋巴细胞和携带 LTPR 的基质细胞之间的定向相互作用参与淋巴组织的组织。
The lymphotoxin beta receptor (LT beta R), and its ligand, LT alpha 1 beta 2, have been proposed to play a key role in the development and organization of lymphoid tissues. The LT beta R is expressed on a variety of human primary and transformed cells, but strikingly absent on T or B lymphocytes and primary monocytes or peripheral dendritic cells, although LT beta R is detected on some myeloid leukemic lines. In the developing thymus LT beta R is prominent along the trabeculae and into the medulla upto corticomedullary junction. In the spleen, LT beta R is prominently expressed by cells in the red pulp and along the borders of red and white pulp which colocalizes with reticular stromal cells. The LT beta R is expressed on a human follicular dendritic cell line, FDC-1, and signals expression of CD54 when ligated with the LT alpha 1 beta 2 complex. These results support the concept that directional interactions between LT alpha 1 beta 2 bearing lymphocytes and LTPR bearing stromal cells are involved in the organization of lymphoid tissue.