APOE e4 polymorphism in young adults is associated with improved attention and indexed by distinct neural signatures.
APOE e4 polymorphism in young adults is associated with improved attention and indexed by distinct neural signatures.
复制标题
年轻人中的 APOE e4 多态性与注意力的改善相关，并通过独特的神经特征进行索引。
DOI：
10.1016/j.neuroimage.2012.10.010
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发表时间：
2013
期刊：
影响因子：
5.7
通讯作者：
Rusted JM
中科院分区：
文献类型：
--
作者：
Rusted JM
APOE e4 等位基因会增加老年人患痴呆症的风险，并且与年轻人认知能力的增强有关。当前研究的一个目标是比较 e4 携带者 (e4+) 和非 e4 携带者 (e4−) 的任务相关行为和神经特征，以帮助阐明这种认知差异背后的潜在机制。在两项注意力测量中，我们记录了年轻成人 e4+ 相对于 e4− 的明显行为优势，这表明 e4+ 以更广泛的注意力执行这些任务。行为优势与功能磁共振成像检测到的任务相关大脑激活增加有关（BOLD）。此外，行为测量与结构测量相关，这些结构测量源自之前对我们队列中白质完整性的 DTI 分析。这些数据为拮抗性多效性假说提供了明确的支持，即 e4 等位基因在生命早期赋予了一些认知优势，尽管在老年时会产生不利后果。这些数据表明结构和功能特征的差异是行为优势的补充中介。
The APOE e4 allele, which confers an increased risk of developing dementia in older adulthood, has been associated with enhanced cognitive performance in younger adults. An objective of the current study was to compare task-related behavioural and neural signatures for e4 carriers (e4+) and non-e4 carriers (e4−) to help elucidate potential mechanisms behind such cognitive differences. On two measures of attention, we recorded clear behavioural advantages in young adult e4+ relative to e4−, suggesting that e4+ performed these tasks with a wider field of attention. Behavioural advantages were associated with increased task-related brain activations detected by fMRI (BOLD). In addition, behavioural measures correlated with structural measures derived from a former DTI analysis of white matter integrity in our cohort. These data provide clear support for an antagonistic pleiotropy hypothesis — that the e4 allele confers some cognitive advantage in early life despite adverse consequences in old age. The data implicate differences in both structural and functional signatures as complementary mediators of the behavioural advantage.