Cytotoxic dihydrobenzophenanthridine alkaloids from the roots of Macleaya microcarpa
Cytotoxic dihydrobenzophenanthridine alkaloids from the roots of Macleaya microcarpa
复制标题
DOI：
10.1016/j.phytochem.2010.02.007
复制
发表时间：
2010-05-01
期刊：
影响因子：
3.8
通讯作者：
Qin, Hai-lin
中科院分区：
文献类型：
--
作者：
Deng, An-jun;Qin, Hai-lin
从博落回(Macleaya Microcarpa)根中分离得到5种二氢苯并菲并菲生物碱，命名为博落回碱A-E，以及10个已知的benzophenanthridine/dihydrobenzophenanthridine衍生物和1个已知的酰胺类化合物。用波谱方法确定了它们的结构。用X-射线单晶衍射法确定了苦杏仁碱A的相对构型，建立了苦杏仁碱B和C的相对构型，并利用其CD曲线对苦杏仁碱A-C的绝对构型进行了归属。对分离出的化合物进行了对5种人肿瘤细胞株的细胞毒性评价，其中一些化合物的IC(50)值在0.1到3.5mU之间。(C)2010爱思唯尔有限公司。
Five dihydrobenzophenanthridine alkaloids, named as maclekarpine A-E, were isolated from the roots of Macleaya microcarpa, together with 10 known benzophenanthridine/dihydrobenzophenanthridine derivatives and a known amide. Their structures were determined on the basis of spectroscopic methods. The relative configuration of maclekarpine A was solved by X-ray single-crystal diffraction, which also contributed to the establishment of the relative configuration of maclekarpine B and C, as well as the assignment of the absolute configuration of maclekarpine A-C with aid of their CD curves. Cytotoxicity of the isolated compounds against five human tumor cell-lines was evaluated, with some having activity with IC(50) values ranging from 0.1 to 3.5 mu M. (C) 2010 Elsevier Ltd. All rights reserved.