Clinical correlates of steady-state oxyhaemoglobin desaturation in children who have sickle cell disease
Clinical correlates of steady-state oxyhaemoglobin desaturation in children who have sickle cell disease
复制标题
DOI：
10.1111/j.1365-2141.2005.05738.x
复制
发表时间：
2005-10-01
影响因子：
6.5
通讯作者：
Ahmad, N
中科院分区：
文献类型：
--
作者：
Quinn, CT;Ahmad, N
镰状细胞病（SCD）患者在稳定状态下可能会出现氧合血红蛋白去饱和，其原因尚不完全清楚。我们研究了一组585名患有镰状细胞贫血（SS）、镰状β（0）-地中海贫血（S β（0））、镰状血红蛋白C病（SC）或镰状β（+）-地中海贫血（Sb+），以确定稳态氧合血红蛋白饱和度（SpO（2））与SCD基因型、年龄、性别、稳态血红蛋白（Hb）和网织红细胞计数之间的关系，急性胸部综合征（ACS）的发生率。SS/S β（0）组（n 390）的平均SpO（2）低于SC/S β（+）组（n 195）（96.3% vs. 98.7%，P < 0.001）。在SS/Sb-0受试者中，稳态SpO（2）降低与Hb降低、网织红细胞增加、年龄较大和男性相关。在SC/Sb+组中未发现这些相关性。既往ACS与稳态SpO无关（2）。多变量模型解释了SpO（2）中45%的变异性，但Hb仅解释了SpO（2）中5%的变异性。我们的结论是稳态去饱和在SCD患者中很常见，但它似乎与之前的ACS发作无关，并且很大程度上无法用慢性贫血解释。
Individuals with sickle cell disease (SCD) may have oxyhaemoglobin desaturation during the steady-state, the causes of which are incompletely known. We studied a cohort of 585 children who have sickle cell anaemia (SS), sickle beta(0)-thalassaemia (S beta(0)), sickle-haemoglobin C disease (SC), or sickle beta(+)-thalassaemia (Sb+) to determine the relationships between steady-state oxyhaemoglobin saturation (SpO(2)) and SCD genotype, age, gender, steady-state haemoglobin (Hb) and reticulocyte count, and rate of acute chest syndrome (ACS). The SS/S beta(0) group (n 390) had lower mean SpO(2) than the SC/S beta(+) group (n 195) (96.3% vs. 98.7%, P < 0.001). Among SS/Sb-0 subjects, a decrease in steady-state SpO(2) correlated with a decrease in Hb, an increase in reticulocytes, older age and male gender. These correlations were not found in the SC/Sb+ group. Prior ACS did not correlate with steady-state SpO(2). A multivariate model explained 45% of the variability in SpO(2), but only 5% of the variation in SpO(2) was explained by Hb. We conclude that steady-state desaturation is common in individuals with SCD, but it appears to be unrelated to prior episodes of ACS and largely unexplained by chronic anaemia.