Plasma C-reactive protein and risk of cancer: A prospective study from Greece
Plasma C-reactive protein and risk of cancer: A prospective study from Greece
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DOI：
10.1158/1055-9965.epi-05-0626
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发表时间：
2006-02-01
影响因子：
3.8
通讯作者：
Boffetta, P
中科院分区：
文献类型：
--
作者：
Trichopoulos, D;Psaltopoulou, T;Boffetta, P
背景资料：炎症是癌症发生的重要组成部分，但很少有研究已经进行了炎症标志物是否可以预测癌症的风险在human.Methods：我们分析了C-反应蛋白（CRP），炎症的标志物，在血浆样本中的496例癌症和996名对照中选择的参与者在希腊的前瞻性研究。恶性肿瘤患者血浆CRP水平高于对照组（CRP水平升高3.2 mg/L的比值比，1.20; 95%置信区间，1.10-1.32）：排除第一年随访和CRP水平高于20 mg/L的个体后，相应的比值比为1.32（95%置信区间，1.15-1.52）。虽然基于少量的情况下，血浆CRP水平升高和风险之间的关联是更强的肝癌，肺癌，皮肤癌，肾癌，膀胱癌，以及淋巴瘤和白血病比其他numerics.Conclusions：我们的研究结果证实了炎症在人类癌症中的重要作用，并建议血浆CRP水平是一个潜在的标志物癌症风险增加。
Background: Inflammation is an important component of carcinogenesis but little research has been conducted on whether inflammation markers can be predictive of cancer risk in humans.Methods: We analyzed C-reactive protein (CRP), a marker of inflammation, in plasma samples of 496 cases of cancer and 996 controls selected among participants in a prospective study from Greece.Results: Plasma CRP level was higher in cancer cases than controls (odds ratio for increase in CRP level of 3.2 mg/L, 1.20; 95% confidence interval, 1.10-1.32): The corresponding odds ratio after exclusion of the first year of follow-up and of individuals with CRP level above 20 mg/L was 1.32 (95% confidence interval, 1.15-1.52). Although based on small number of cases, the association between elevated plasma CRP level and risk was stronger for cancers of the liver, lung, skin, kidney, and bladder, as well as for lymphoma and leukemia than for other neoplasms.Conclusions: Our results confirm the important role of inflammation in human cancer and suggest that plasma CRP level is a potential marker of increased cancer risk.