Why We Do Not Yet Understand the Genetics of Affective Disorders
Why We Do Not Yet Understand the Genetics of Affective Disorders
复制标题
为什么我们还不了解情感障碍的遗传学
DOI：
10.1007/978-1-4684-2397-6_6
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发表时间：
1978
影响因子：
2.5
通讯作者：
M. Weissman
中科院分区：
文献类型：
--
作者：
K. Kidd;M. Weissman
至少有相当好的证据表明，某些类型的情感障碍具有遗传成分。因此，最近有许多关于支持情感障碍遗传假说的数据综述。1 -4由于在过去几年中没有出现显著的新证据，这些综述仍然提供了很好的数据摘要。然而，对这些数据的解释发生了相当大的争论，在这一领域正在形成新的想法。在本章中，我们将简要回顾确定遗传成分是否存在所需的证据，讨论与情感性精神障碍的遗传方式相关的现有数据和分析，最后讨论为了解决不确定性仍然需要的数据类型。这些类型的数据的缺乏和获得它们的困难解释了为什么我们还不了解情感障碍的遗传学，正如我们将展示的那样。
Reasonably good evidence exists for at least some types of affective disorders having a genetic component. Consequently, there are many recent reviews of the data supporting genetic hypotheses for the affective disorders.1–4 Since no remarkable new evidence has appeared in the last couple of years, those reviews still provide good summaries of the data. However, considerable debate occurs over the interpretation of these data, and new thoughts are developing in this area. In this chapter we shall briefly review the evidence needed for determining whether a genetic component exists, discuss the current data and analyses relative to mode(s) of inheritance for affective disorders, and finally discuss the types of data that are still required in order to resolve the uncertainties. The absence of these types of data and the difficulty in obtaining them explain, as we shall show, why we do not yet understand the genetics of affective disorders.