Polymer-supported O-methylisourea:: A new reagent for the O-methylation of carboxylic acids
Polymer-supported O-methylisourea:: A new reagent for the O-methylation of carboxylic acids
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DOI：
10.1021/ol025633s
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发表时间：
2002-03-21
期刊：
影响因子：
5.2
通讯作者：
Linclau, B
中科院分区：
文献类型：
--
作者：
Crosignani, S;White, PD;Linclau, B
[图解]以市售的固载碳二亚胺为原料，一步合成了固载O-甲基异硫脲试剂。异脲试剂已成功地用于由相应的羧酸制备甲酯。树脂过滤和溶剂挥发后得到的粗品一般纯度为&98%。
[GRAPHICS]A solid-supported O-methylisourea reagent has been prepared in one step starting from commercially available solid-supported carbodiimide. The isourea reagent has been successfully used for the preparation of methyl esters from the corresponding carboxylic acids. The crude products obtained after resin filtration and solvent evaporation are generally obtained in >98% purity.