Age-related cardiac disease model of Drosophila
Age-related cardiac disease model of Drosophila
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DOI：
10.1016/j.mad.2006.11.023
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发表时间：
2007-01-01
影响因子：
5.3
通讯作者：
Bodmer, Rolf
中科院分区：
文献类型：
--
作者：
Ocorr, Karen;Akasaka, Takeshi;Bodmer, Rolf
我们已经开始研究果蝇心脏功能恶化的遗传基础，作为与年龄相关的心脏疾病模型。为此，我们在果蝇身上进行了心脏功能测试，发现果蝇的心脏性能，就像人类的心脏一样，随着年龄的增长而恶化：老化的果蝇表现出电动起搏导致的心力衰竭和心律失常的逐渐增加。胰岛素受体和相关的通路对果蝇与年龄相关的心脏功能有戏剧性的和心脏自主的影响，这表明在调节脊椎动物的心脏衰老方面可能存在类似的机制。KCNQ和K-ATP离子通道功能受损似乎也是导致老年果蝇心脏功能下降的原因，这表明相应的脊椎动物基因功能可能随着年龄的增长而下降，此外，它们分别在防止心律失常和缺氧/缺血方面发挥着保守的作用。果蝇心脏因此成为研究器官功能与年龄相关的衰退的一种很有前途的遗传模型。(C)2006爱思唯尔爱尔兰有限公司。保留所有权利。
We have begun to study the genetic basis of deterioration of cardiac function in the fruit fly Drosophila melanogaster as an age-related cardiac disease model. For this purpose we have developed heart function assays in Drosophila and found that the fly's cardiac performance, as that of the human heart, deteriorates with age: aging fruit flies exhibit a progressive increase in electrical pacing-induced heart failure as well as in arrhythmias. The insulin receptor and associated pathways have a dramatic and heart-autonomous influence on age-related cardiac performance in flies, suggestive of potentially similar mechanisms in regulating cardiac aging in vertebrates. Compromised KCNQ and K-ATP ion channel functions also seem to contribute to the decline in heart performance in aging flies, suggesting that the corresponding vertebrate gene functions may similarly decline with age, in addition to their conserved role in protecting against arrhythmias and hypoxia/ischemia, respectively. The fly heart is thus emerging as a promising genetic model for studying the age-dependent decline in organ function. (c) 2006 Elsevier Ireland Ltd. All rights reserved.