Protective effects of S-allylcysteine on hepatic glutathione and glutathione-dependent enzymes during hamster cheek pouch carcinogenesis.
Protective effects of S-allylcysteine on hepatic glutathione and glutathione-dependent enzymes during hamster cheek pouch carcinogenesis.
复制标题
S-烯丙基半胱氨酸对仓鼠颊囊癌发生过程中肝谷胱甘肽和谷胱甘肽依赖性酶的保护作用。
DOI：
10.1080/10258140290010160
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
S. Nagini
中科院分区：
文献类型：
--
作者：
S. Balasenthil;S. Nagini
研究了7,12-二甲基苯[a]蒽（DMBA）诱导的雄性叙利亚仓鼠颊袋癌（HBP）发生过程中s -丙烯基半胱氨酸（SAC）对肝脏脂质过氧化和抗氧化状态的影响。荷瘤动物肝脏脂质过氧化作用增强，伴有谷胱甘肽过氧化物酶（GPx）和谷胱甘肽s -转移酶（GST）活性显著降低，还原型谷胱甘肽（GSH）水平降低。施用SAC可显著减少脂质过氧化物的形成，提高抗氧化剂和解毒酶的水平。我们认为，SAC升高肝脏GSH和GSH依赖性酶可能在预防仓鼠颊袋癌发展中起关键作用。
The effects of S-allylcysteine (SAC) on hepatic lipid peroxidation and antioxidant status during 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis (HBP) were investigated in male Syrian hamsters. Enhanced lipid peroxidation in the liver of tumour-bearing animals was accompanied by significant decreases in the activities of glutathione peroxidase (GPx) and glutathione S-transferase (GST) and a reduction in reduced glutathione (GSH) levels. Administration of SAC significantly decreased the formation of lipid peroxides and enhanced the levels of antioxidants and detoxifying enzymes. We suggest that the elevation of hepatic GSH and GSH-dependent enzymes by SAC may play a key role in preventing cancer development in the hamster cheek pouch.