Effect of Tryptophan on Nuclear Envelope Nucleoside Triphosphatase Activity in Rat Liver 1
Effect of Tryptophan on Nuclear Envelope Nucleoside Triphosphatase Activity in Rat Liver 1
复制标题
色氨酸对大鼠肝脏核包膜核苷三磷酸酶活性的影响1
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
H. Sidransky
中科院分区：
文献类型：
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作者：
C. Murty;E. Verney;H. Sidransky
在接受单管饲色氨酸的大鼠肝脏中研究了核膜核苷三磷酸酶（一种参与mRNA核质易位的酶）的活性。色氨酸给药禁食大鼠或嘌呤霉素或放线菌素D预处理的大鼠引起显着增加的活性Mg 2+依赖性核苷三磷酸酶在肝核膜中的控制。伴随着这种快速（10分钟）的酶活性的增加，有更多的释放RNA从分离的细胞核的肝脏的Dahan治疗的大鼠比对照组大鼠。
Summary The activity of nuclear envelope nucleoside triphosphatase, an enzyme implicated to be involved in nucleocytoplasmic translocation of mRNA, was investigated in the livers of rats that received a single tube-feeding of tryptophan. Tryptophan administered to fasted rats or to rats pretreated with puromycin or actinomycin D caused significant increases in the activity of Mg2+-dependent nucleoside triphosphatase in the hepatic nuclear envelopes over that in controls. Concomitant with this rapid (10 min) increase in the enzyme activity, there was more release of RNA from isolated nuclei of livers of tryptophan-treated rats than from those of control rats.