Ethanol extracts from Hemerocallis citrina attenuate the upregulation of proinflammatory cytokines and indoleamine 2,3-dioxygenase in rats
Ethanol extracts from Hemerocallis citrina attenuate the upregulation of proinflammatory cytokines and indoleamine 2,3-dioxygenase in rats
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黄花菜乙醇提取物可减弱大鼠促炎细胞因子和吲哚胺 2,3-双加氧酶的上调
DOI：
10.1016/j.jep.2014.03.001
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发表时间：
2014-04-28
影响因子：
5.4
通讯作者：
Yi, Li-Tao
中科院分区：
文献类型：
--
作者：
Liu, Xiao-Long;Luo, Liu;Yi, Li-Tao
民族药理学相关性：黄花菜是一种传统的草药，在东亚国家已被用于改善行为和情绪状态。在我们实验室以前的研究表明，从黄花菜（HCE）乙醇提取物增强单胺类和脑源性神经营养因子（BDNF）在抑郁样modelofmarticle.Materials和方法：本研究延长早期的作品中的作用，抗炎调节抗抑郁样行动的HCE暴露于慢性不可预测的温和的压力（CIMIS）。HCE治疗4周后，测定大鼠额叶皮质和海马促炎细胞因子水平和吲哚胺2，3-双加氧酶（IDO）活性。结果：HCE慢性给药逆转了蔗糖偏好实验中降低的蔗糖偏好性。此外，我们还发现HCE抑制白细胞介素-1 β，（IL-1 β）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）的表达，以及额叶皮质和海马中IDO的活性，在暴露于COMS的大鼠中增加。结合我们以往的研究，我们目前的发现表明，HCE的抗炎特性可能在其抗抑郁样作用中起关键作用，至少部分是通过，恢复或改善单胺能和神经营养素系统。(C)2014爱思唯尔爱尔兰有限公司版权所有。
Ethnopharmacological relevance: Hemerocallis citrina, a traditional herbal medicine, has been used for the improvement of behavioral and emotional status in Eastern-Asia countries. Previous studies in our laboratory demonstrated that ethanol extracts from Hemerocallis citrina (HCE) enhanced monoamines and brain-derived neurotrophic factor (BDNF) in depression-like model of rodents.Materials and methods: The present study extends earlier works on the role of anti-inflammation in regulating the antidepressant-like actions of HCE in rats exposed to chronic unpredictable mild stress (CUMS). Frontal cortex and hippocampal proinflammatory cytokines levels and indoleamine 2,3-dioxygenase (IDO) activity were measured after 4-week HCE treatment in the CUMS an control rats.Results: Chronic administration of HCE reversed the decreased sucrose preference in sucrose preference test. In addition, we also found that HCE inhibited interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) expression, as well as IDO activity in frontal cortex and hippocampus, which were increased in rats exposed to CUMS.Conclusions: Combining with our previous studies, our present finding suggests that the anti-inflammatory property of HCE might play a crucial role in its antidepressant-like effect through, at least in part, the restoration or improvement of monoaminergic and neurotrophin systems. (C) 2014 Elsevier Ireland Ltd. All rights reserved.