P-selectin expression in a metastatic pancreatic tumor cell line (SUIT-2).
P-selectin expression in a metastatic pancreatic tumor cell line (SUIT-2).
复制标题
DOI：
--
复制
发表时间：
1997-03
期刊：
影响因子：
11.2
通讯作者：
T. Iwamura;T. Caffrey;N. Kitamura;H. Yamanari;T. Setoguchi;M. Hollingsworth
中科院分区：
文献类型：
--
作者：
T. Iwamura;T. Caffrey;N. Kitamura;H. Yamanari;T. Setoguchi;M. Hollingsworth
人类胰腺肿瘤细胞系SUIT-2来源于胰腺腺癌患者肝脏的转移灶。SUIT-2及其衍生的克隆细胞系在s.c.裸鼠异种移植物中可自发转移到肺和局部淋巴结，并表达p -选择素mRNA和蛋白。胰腺肿瘤细胞暴露于凝血酶、氧自由基和胰蛋白酶后，p -选择素蛋白的表面表达增加，提示血小板、内皮细胞和这些胰腺肿瘤细胞中存在调节p -选择素表面表达的共同细胞机制。p -选择素在转移性胰腺肿瘤细胞中表达的发现表明，表达这些粘附分子的细胞类型范围比之前认为的要广泛。
The human pancreatic tumor cell line SUIT-2 was derived from a metastatic lesion in the liver of a patient with pancreatic adenocarcinoma. SUIT-2 and clonal cell lines derived from it show spontaneous metastasis to lung and regional lymph nodes from s.c. nude mouse xenografts and were found to express P-selectin mRNA and protein. Surface expression of P-selectin protein was increased by exposure of the pancreatic tumor cells to thrombin, oxygen radicals, and trypsin, suggesting that common cellular mechanisms for regulating P-selectin surface expression exist among platelets, endothelial cells, and these pancreatic tumor cells. The finding that P-selectin is expressed by metastatic pancreatic tumor cells demonstrates that the range of cell types that express these adhesion molecules is broader than believed previously.