Alpha-glucosidase inhibitors
Alpha-glucosidase inhibitors
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DOI：
10.1016/s0889-8529(05)70266-8
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发表时间：
1997-09-01
影响因子：
4.5
通讯作者：
Lebovitz, HE
中科院分区：
文献类型：
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作者：
Lebovitz, HE
α -葡萄糖苷酶抑制剂是一种抗高血糖药物，通过延缓复杂碳水化合物的消化和吸收来降低血糖。它们是肠细胞刷状边界酶的竞争性抑制剂，这些酶将低糖切割成单糖。它们的主要作用是降低餐后血糖的升高。在非胰岛素依赖型糖尿病患者中，这些抑制剂可使餐后血糖降低40 - 50mg /dL，使血红蛋白A（1c）降低0.5% - 1.0%。
Alpha-glucosidase inhibitors are antihyperglycemic agents that lower blood glucose by delaying the digestion and absorption of complex carbohydrates. They are competitive inhibitors of the enzymes in the brush border of enterocytes that cleave eligosaccharides to monosaccharides. Their major action is to reduce the rise of postprandial plasma glucose. In non-insulin-dependent diabetes mellitus patients, these inhibitors decrease postprandial plasma glucose by 40 to 50 mg/dL and hemoglobin A(1c) by 0.5% to 1.0%.