Engineering Inorganic Nanoemulsions/Nanoliposomes by Fluoride-Silica Chemistry for Efficient Delivery/Co-Delivery of Hydrophobic Agents
Engineering Inorganic Nanoemulsions/Nanoliposomes by Fluoride-Silica Chemistry for Efficient Delivery/Co-Delivery of Hydrophobic Agents
复制标题
通过氟化物-二氧化硅化学工程设计无机纳米乳液/纳米脂质体，以实现疏水剂的高效递送/共同递送
DOI：
10.1002/adfm.201102052
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发表时间：
2012-04-24
影响因子：
19
通讯作者：
Shi, Jianlin
中科院分区：
文献类型：
--
作者：
Chen, Yu;Gao, Yu;Shi, Jianlin
采用无机介孔二氧化硅纳米胶囊（imnc）替代传统的有机乳剂和脂质体，在保留无机材料优点的同时，提出了一种新的药物配方方案，以解决疏水药物分子的递送问题。imnc的独特结构是由基于结构差异的选择性蚀刻策略的新型氟化物-二氧化硅化学设计的。所制备的纳米碳纳米管结合了有机纳米乳剂或纳米脂质体的功能和无机材料的特性。通过改变合成参数，可以简单地制备出各种球形纳米结构。典型的高疏水性抗癌药物喜树碱（CPT）在imnc中的载药量高达35.1% wt%。CPT从载体的细胞内释放被原位证明。此外，imnc可以发挥有机纳米脂质体（多泡脂质体）的作用，同时包封和递送疏水（CPT）和亲水（阿霉素、DOX）抗癌药物。多种药物在同一载体上的共递送和药物组合在细胞内的释放，使药物递送系统能够有效增强对dox耐药MCF-7/ADR癌细胞的化疗效果。作为一种概念验证，这种特殊的基于imncs的无机纳米乳也可以成功地用于包封和递送生物相容性疏水性全氟己烷（PFH）分子，用于高强度聚焦超声（HIFU）的体外和体内协同治疗。基于这种新颖的设计策略，将开发出一系列具有类似无机纳米乳或纳米脂质体功能的无机材料系统，以满足不同的临床需求。
A novel drug-formulation protocol is developed to solve the delivery problem of hydrophobic drug molecules by using inorganic mesoporous silica nanocapsules (IMNCs) as an alternative to traditional organic emulsions and liposomes while preserving the advantages of inorganic materials. The unique structures of IMNCs are engineered by a novel fluoride-silica chemistry based on a structural difference-based selective etching strategy. The prepared IMNCs combine the functions of organic nanoemulsions or nanoliposomes with the properties of inorganic materials. Various spherical nanostructures can be fabricated simply by varying the synthetic parameters. The drug loading amount of a typical highly hydrophobic anticancer drug-camptothecin (CPT) in IMNCs reaches as high as 35.1 wt%. The intracellular release of CPT from carriers is demonstrated in situ. In addition, IMNCs can play the role of organic nanoliposome (multivesicular liposome) in co-encapsulating and co-delivering hydrophobic (CPT) and hydrophilic (doxorubicin, DOX) anticancer drugs simultaneously. The co-delivery of multi-drugs in the same carrier and the intracellular release of the drug combinations enables a drug delivery system with efficient enhanced chemotherapeutic effect for DOX-resistant MCF-7/ADR cancer cells. The special IMNCs-based inorganic nanoemulsion, as a proof-of-concept, can also be employed successfully to encapsulate and deliver biocompatible hydrophobic perfluorohexane (PFH) molecules for high intensity focused ultrasound (HIFU) synergistic therapy ex vivo and in vivo. Based on this novel design strategy, a wide range of inorganic material systems with similar inorganic nanoemulsion or nanoliposome functions will be developed to satisfy varied clinical requirements.