Early reattachment does not reverse atrophy and fat accumulation of the supraspinatus - an experimental study in rabbits
Early reattachment does not reverse atrophy and fat accumulation of the supraspinatus - an experimental study in rabbits
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DOI：
10.1016/s0736-0266(02)00208-5
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发表时间：
2003-05-01
影响因子：
2.8
通讯作者：
Himori, K
中科院分区：
文献类型：
--
作者：
Uhthoff, HK;Matsumoto, F;Himori, K
引言：冈上肌腱自发性断裂后的再附着可改善肩关节功能。这种功能的改善是否是由于SSP破裂后已知发生的肌肉萎缩和脂肪积累的逆转仍有争议。我们以前的研究后期再附着的SSP（12周）未能确认肌肉萎缩和脂肪accumulation.Purpose的逆转：为了找出是否早期再附着（6周）逆转萎缩和脂肪accumulationofthe SSP.Material and Methods：再附着组：在7只兔单侧冈上肌脱离，6周后再附着，6周后处死。分离组：7只兔单侧冈上肌分离，12周后处死。对侧肩关节作为对照（n = 14）。冈上肌成分的测定：肌肉、肌外脂肪和肌内脂肪的体积和横截面积。结果：再附着组的肌肉组织（8.6 ml +/- 1 s.d. = 0.6）和脱离组（8.9 ml +/- 0.9）低于对照组（10.2 ml +/- 0.9，均P < 0.05）。再附着组（8.7% ± 3.2）的肌外脂肪和肌内脂肪均大于分离组（4.6% ± 3.5）和对照组（2.8% ± 1.7，均p < 0.05）。结论：在兔中，6周时SSP再附着既不能逆转肌肉萎缩，也不能逆转随后6周内的脂肪堆积。然而，早期再附着（6周）与晚期再附着（12周）相比，防止了脂肪积累的增加。另一方面，肌腱重新附着前的延迟并没有导致肌肉萎缩的增加。(C)2003骨科研究学会。由爱思唯尔科技有限公司出版。保留所有权利。
Introduction: Reattachment of the supraspinatus (SSP) tendon after spontaneous rupture leads to improved shoulder function. Whether this improvement of function is due to a reversal of muscle atrophy and fat accumulation known to occur after SSP rupture is still debated. Our previous study of late reattachment of SSP (12 weeks) failed to confirm a reversal of muscle atrophy and of fat accumulation.Purpose: To find out whether earlier reattachment (6 weeks) reverses atrophy and fat accumulation of the SSP.Material and methods: Reattachment group: in seven rabbits unilateral supraspinatus detachment, reattachment after 6 weeks and killing 6 weeks later. Detachment group: in seven rabbits unilateral supraspinatus detachment and killing 12 weeks later. The contralateral shoulders served as controls (n = 14). Determination of the supraspinatus constituents: muscle, extra- and intramuscular fat in volume and cross-sectional area.Results: Muscle tissue in the reattachment group (8.6 ml +/- 1 s.d. = 0.6) and in the detachment group (8.9 ml +/- 0.9) were less than in control supraspinati (10.2 ml +/- 0.9, both p < 0.05). Extra- and intramuscular fat in the reattachment group (8.7% ± 3.2) was greater than in both, the detachment group (4.6% ± 3.5), and control supraspinati (2.8% ± 1.7, both p < 0.05).Conclusion: In the rabbit, reattachment of the SSP at 6 weeks did neither reverse muscle atrophy nor fat accumulation during the ensuing 6 weeks. However, earlier reattachment (6 weeks) when compared with later reattachment (12 weeks) prevented an increase in fat accumulation. On the other hand, the delay before reattaching the tendon did not lead to an increase in muscle atrophy. (C) 2003 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.