Ketamine successfully terminates malignant status epilepticus
Ketamine successfully terminates malignant status epilepticus
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DOI：
10.1016/j.eplepsyres.2008.08.005
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发表时间：
2008-12-01
影响因子：
2.2
通讯作者：
Holtkamp, Martin
中科院分区：
文献类型：
--
作者：
Pruess, Harald;Holtkamp, Martin
A 22-year-old woman with mitochondriopathy and pre-existing epilepsy developed status epilepticus (SE) not responding to benzodiazepines, phenytoin, thiopental, and propofol. SE was terminated within days after supplemental administration of continuous ketamine infusion to midazolam. The case suggests strong anticonvulsant properties of ketamine even failure of GABAergic anesthetics, likely due to increased NMDA receptor expression with after. ongoing seizure activity. Thus, ketamine should be incorporated into therapeutic regimens for difficult-to-treat SE. (C) 2008 Elsevier B.V. All rights reserved.
