Unconventional recognition of peptides by T cells and the implications for autoimmunity
Unconventional recognition of peptides by T cells and the implications for autoimmunity
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DOI：
10.1038/nri3294
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发表时间：
2012-10-01
影响因子：
100.3
通讯作者：
Unanue, Emil R.
中科院分区：
文献类型：
--
作者：
Mohan, James F.;Unanue, Emil R.
抗原提呈细胞与游离肽或变性蛋白的相互作用可产生有别于处理整个蛋白质后产生的多肽-MHC II类复合体。这种非典型的多肽-MHC复合体可以被非常规的B类T细胞识别，这些B类T细胞不是对蛋白质的正常免疫反应的组成部分。重要的是，这些非常规T细胞可以在自身免疫的环境中找到。在这里，我们讨论了B型T细胞的非常规多肽识别，并考虑了它对1型糖尿病和其他自身免疫性疾病的影响。
The interaction of antigen-presenting cells with free peptides or a denatured protein can give rise to peptide-MHC class II complexes that are distinct from those generated after the processing of the whole protein. Such atypical peptide-MHC complexes can be recognized by unconventional 'type B' T cells that are not a component of the normal immune response to proteins. Importantly, these unconventional T cells can be found in the setting of autoimmunity. Here, we discuss unconventional peptide recognition by type B T cells and consider the implications for type 1 diabetes and other autoimmune diseases.