Demonstration of intrathecal and systemic morphine and ST-91 effects on fed canine upper gut motility.
Demonstration of intrathecal and systemic morphine and ST-91 effects on fed canine upper gut motility.
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演示鞘内和全身吗啡和 ST-91 对进食犬上消化道运动的影响。
DOI：
10.1007/bf01536415
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发表时间：
1990
影响因子：
3.1
通讯作者：
Yaksh,TL
中科院分区：
文献类型：
--
作者：
Thomforde,GM;Malagelada,JR;Camilleri,M;Yaksh,TL
我们研究了阿片类和肾上腺素能激动剂和拮抗剂的影响，全身静脉和鞘内餐后胃窦和小肠运动在一个慢性清醒的狗模型。我们研究了八只狗与手术植入胸脊髓鞘内注射导管，和六胃肠测压灌注导管。鞘内或静脉注射吗啡可引起进食狗肠内压力活动的扩散。吗啡的最小有效剂量鞘内注射为150 μg/kg，静脉注射为450 μg/kg。ST-91（一种α2-肾上腺素能激动剂）对胃窦和小肠压力活动具有显著抑制作用，静脉和鞘内给药途径的最小有效剂量（100 μg/kg）和作用持续时间相似。纳洛酮（3000 μg/kg）或酚妥拉明（1500 μg/kg）与普萘洛尔（300 μg/kg）合用均不改变餐后胃窦或小肠运动。研究了药物在同一隔室（静脉内或鞘内）给药时阻断吗啡诱导的活动前沿的能力。纳洛酮的最低有效吗啡拮抗剂剂量鞘内注射和静脉注射相似（两种途径均为36 μg/kg）。ST-91（100 μg/kg）鞘内或静脉内给药时，阻断吗啡诱导的簇状相位压力活动，同时消除餐后小肠相位压力活动。这些数据表明，脊髓中存在阿片样物质和α2-肾上腺素能受体，可调节餐后状态下的胃肠动力。这些系统之间的药理学相互作用发生在脊髓和靶器官水平。
We studied the effects of opioid and adrenergic agonists and antagonists given systemically intravenously and intrathecally on postprandial antral and small bowel motility in a chronic conscious dog model. We studied eight dogs with a surgically implanted thoracic spinal intrathecal injection catheter, and six gastrointestinal manometric perfusion catheters. Morphine given intrathecally or intravenously induced propagated clusters of intestinal pressure activity in the fed dogs. The minimal effective dose for morphine was 150 μg/kg by the intrathecal route and 450 μg/kg by the intravenous route. ST-91 (an α2-adrenergic agonist) profoundly inhibited antral and small intestinal pressure activity with similar minimal effective dose (100 μg/kg) and duration of effect for both intravenous and intrathecal routes. Neither naloxone (3000 μg/kg) nor combined phentolamine (1500 μg/kg) with propranolol (300 μg/kg) altered postprandial antral or small intestinal motility. The capacity of pharmacologic agents to block morphine-induced activity fronts when administered in the same compartment (intravenously or intrathecally) was investigated. The minimally effective morphine-antagonist dose for naloxone was similar intrathecally and intravenously (36 μg/kg for both routes). ST-91 (100 μg/kg) when given intrathecally or intravenously blocked morphine-induced clustered phasic pressure activity while simultaneously abolishing postprandial small intestine phasic pressure activity. These data suggest the presence of opioid and α2-adrenergic receptors in the spinal cord that can modulate gastrointestinal motility in the postprandial state. Pharmacological interactions between these systems occur at spinal and target organ levels.