Copper-Free "Click" Modification of DNA via Nitrile Oxide-Norbornene 1,3-Dipolar Cycloaddition
Copper-Free "Click" Modification of DNA via Nitrile Oxide-Norbornene 1,3-Dipolar Cycloaddition
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DOI：
10.1021/ol9005322
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发表时间：
2009-06-04
期刊：
影响因子：
5.2
通讯作者：
Carell, Thomas
中科院分区：
文献类型：
--
作者：
Gutsmiedl, Katrin;Wirges, Christian T.;Carell, Thomas
在无铜点击反应中，氧化腈与降冰片烯修饰的DNA平稳且快速地发生反应。该反应允许在固体支持物上甚至在合成仪中直接用多种分子对寡脱氧核糖核苷酸（ODN）进行高密度官能化，而无需额外的催化剂。
Nitrile oxides react smoothly and rapidly with norbornene-modified DNA in a copper-free click reaction. The reaction allows high density functionalization of oligodeoxyribonucleotides (ODNs) with a large variety of molecules directly on solid supports and even in synthesizers without the need for an additional catalyst.