The PHD finger of Spp1 mediates histone modification cross-talk.

The PHD finger of Spp1 mediates histone modification cross-talk.
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Spp1 的 PHD 手指介导组蛋白修饰串扰。

DOI:
10.1042/bcj20190492
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发表时间:
2019
期刊:
The Biochemical journal
影响因子:
--
通讯作者:
Kutateladze,TatianaG
Kutateladze,TatianaG
中科院分区:
--
文献类型:
--
作者:
Musselman,CatherineA;Kutateladze,TatianaG

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Spp 1 PHD指与组蛋白H3 K4 me 3的结合对组蛋白尾部的相邻翻译后修饰敏感。这篇评论讨论了他和同事们的发现[Biochem.J.476,1957-1973],这些发现表明PHD指以选择性的方式结合H3 K4 me 3,这在粟酒酵母和哺乳动物Spp 1的直向同源物中是保守的。
Binding of the Spp1 PHD finger to histone H3K4me3 is sensitive to adjacent post-translational modifications in the histone tail. This commentary discusses the findings of He and colleagues [Biochem. J.476, 1957–1973] which show that the PHD finger binds to H3K4me3 in a selective manner which is conserved in theSaccharomyces pombeand mammalian orthologues of Spp1.
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