Reading problems and major mental disorders - co-occurrences and familial overlaps in a Swedish nationwide cohort
Reading problems and major mental disorders - co-occurrences and familial overlaps in a Swedish nationwide cohort
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DOI：
10.1016/j.jpsychires.2017.03.014
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发表时间：
2017-08-01
影响因子：
4.8
通讯作者：
Plomin, Robert
中科院分区：
文献类型：
--
作者：
Cederlof, Martin;Maughan, Barbara;Plomin, Robert
阅读问题通常与多动症和品行障碍同时发生。然而，阅读问题和其他精神疾病的共同发生和家族重叠的模式还没有系统地探讨。我们进行了一项基于登记册的队列研究，包括8719名阅读有问题的人及其兄弟姐妹，沿着匹配的对照个体。条件Logistic回归估计了有阅读问题的个体及其兄弟姐妹患ADHD、自闭症、强迫症、神经性厌食症、精神分裂症、双相情感障碍、抑郁症、物质使用障碍和暴力/非暴力犯罪的风险。精神疾病的诊断由医生指定，并从瑞典国家患者登记册中确定，犯罪定罪则从瑞典国家犯罪登记册中确定。我们发现，有阅读问题的个体患所有精神疾病（神经性厌食症除外）和犯罪的风险都很高，风险比在1.34到4.91之间。对有阅读问题的个体进行的调查显示，多动症、自闭症、精神分裂症、双相情感障碍、抑郁症、物质使用障碍和非暴力犯罪的风险过高，风险比在1.14和1.70之间。总之，有阅读问题的人几乎增加了所有精神疾病和犯罪的风险。大多数重叠的起源是家族性的，因为有阅读问题的个体的兄弟姐妹也有ADHD、自闭症、精神分裂症、双相情感障碍、抑郁症、物质使用障碍和非暴力犯罪的风险升高。这些发现对基因搜索工作有启示，并建议卫生保健从业者应警惕存在阅读问题的家庭中精神疾病的迹象。(C)2017爱思唯尔有限公司版权所有
Reading problems often co-occur with ADHD and conduct disorder. However, the patterns of co-occurrence and familial overlap between reading problems and other psychiatric disorders have not been systematically explored. We conducted a register-based cohort study including 8719 individuals with reading problems and their siblings, along with matched comparison individuals. Conditional logistic regressions estimated risks for ADHD, autism, obsessive-compulsive disorder, anorexia nervosa, schizophrenia, bipolar disorder, depression, substance use disorder, and violent/non-violent criminality in individuals with reading problems and their siblings. Diagnoses of psychiatric disorders were physician-assigned and ascertained from the Swedish National Patient Register, and crime convictions from the Swedish National Crime Register. We found that individuals with reading problems had excess risks for all psychiatric disorders (except anorexia nervosa) and criminality, with risk ratios between 1.34 and 4.91. Siblings of individuals with reading problems showed excess risks for ADHD, autism, schizophrenia, bipolar disorder, depression, substance use disorder, and non-violent criminality, with risk ratios between 1.14 and 1.70. In summary, individuals with reading problems had increased risks of virtually all psychiatric disorders, and criminality. The origin of most of these overlaps was familial, in that siblings of individuals with reading problems also had elevated risks of ADHD, autism, schizophrenia, bipolar disorder, depression, substance use disorder, and non-violent criminality. These findings have implications for gene-searching efforts, and suggest that health care practitioners should be alert for signs of psychiatric disorders in families where reading problems exist. (C) 2017 Elsevier Ltd. All rights reserved.