Heterogeneity of human serum antibody responses to P. gingivalis in periodontitis: Effects of age, race/ethnicity, and sex
Heterogeneity of human serum antibody responses to P. gingivalis in periodontitis: Effects of age, race/ethnicity, and sex
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DOI：
10.1016/j.imlet.2019.12.004
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发表时间：
2020-02-01
影响因子：
4.4
通讯作者：
Dawson, D. R., III
中科院分区：
文献类型：
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作者：
Ebersole, J. L.;Al-Sabbagh, M.;Dawson, D. R., III
老年人显示牙周炎的患病率和严重程度增加，尽管这些发现的机制仍然知之甚少。本报告研究了牙龈卟啉单胞菌与疾病存在和患者人口统计学相关的抗原多样性。在426名参与者[牙周健康（n = 61）、牙龈炎（N = 66）或不同程度的牙周炎（N = 299）]中测量牙龈卟啉单胞菌菌株ATCC 33277、FDC 381、W50（ATCC 53978）、W83、A7 A1 -28（ATCC 53977）和A7436的血清IgG抗体。我们假设牙龈卟啉单胞菌的抗原多样性可能导致牙周病慢性感染缺乏“免疫力”。在所有菌株中，最老年龄组的抗体水平低于最年轻组，严重牙周炎患者的抗体水平并不随年龄增长而升高。虽然任何年龄组中80%的牙周炎患者对至少一种牙龈卟啉单胞菌菌株表现出升高的反应，但老年组中的个体反应模式也与其他年龄组显著不同。显着更多的老年患者显示菌株特异性抗体谱仅1株。研究结果支持牙龈卟啉单胞菌可能在患者体内表现出抗原多样性/漂移，并且可能是帮助解释适应性免疫应答在管理感染方面的无效性/无效性的一个因素。
Aging humans display an increased prevalence and severity of periodontitis, although the mechanisms underlying these findings remain poorly understood. This report examined antigenic diversity of P. gingivalis related to disease presence and patient demographics. Serum IgG antibody to P. gingivalis strains ATCC33277, FDC381, W50 (ATCC53978), W83, A7A1-28 (ATCC53977) and A7436 was measured in 426 participants [periodontally healthy (n = 61), gingivitis (N = 66) or various levels of periodontitis (N = 299)]. We hypothesized that antigenic diversity in P. gingivalis could contribute to a lack of "immunity" in the chronic infections of periodontal disease. Across the strains, the antibody levels in the oldest age group were lower than in the youngest groups, and severe periodontitis patients did not show higher antibody with aging. While 80 % of the periodontitis patients in any age group showed an elevated response to at least one of the P. gingivalis strains, the patterns of individual responses in the older group were also substantially different than the other age groups. Significantly greater numbers of older patients showed strain-specific antibody profiles to only 1 strain. The findings support that P. gingivalis may demonstrate antigenic diversity/drift within patients and could be one factor to help explain the inefficiency/ineffectiveness of the adaptive immune response in managing the infection.