The temporal redistribution pattern of NK cells under acute stress based on CD62L adhesion molecule expression
The temporal redistribution pattern of NK cells under acute stress based on CD62L adhesion molecule expression
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DOI：
10.1016/j.ijpsycho.2008.05.580
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发表时间：
2008-10-01
影响因子：
3
通讯作者：
Ohira, Hideki
中科院分区：
文献类型：
--
作者：
Kimura, Kenta;Isowa, Tokiko;Ohira, Hideki
最近的研究表明，急性心理应激会引起淋巴细胞重新分布的一过性变化。早期的研究证实，CD3-CD16+CD56+自然杀伤细胞(NK细胞)在外周血循环中显著增加，NK细胞中淋巴细胞的重新分布数量依赖于CD62L的表达密度，尤其是CD62L-细胞比CD62L+细胞动员得更明显。这些结果导致我们假设这种不同的反应性导致CD62L+和CD62L-淋巴细胞亚群之间不同的时间特征。10名女性参与者经历了10分钟的基准期，并执行了10分钟的心算任务，作为急性心理压力源。于实验结束后即刻及每隔2分钟采血测定CD62L+或CD62L-NK细胞及CD62L+或CD62L-T细胞的比例。不出所料，CD62L+和CD62L-NK细胞对应激源的反应不同，表现出不同的时间特征。即CD62L-NK细胞在应激后1min达到显著升高水平，CD62L+NK细胞在8min后有升高趋势。虽然CD3+T细胞在不同类型的CD62L细胞中表现出不同的反应性，但它们没有表现出不同的时间特征。这些结果表明，CD62L的表达不仅调节NK细胞再分布的数量，而且还调节NK细胞再分布的时间特征。(C)2008爱思唯尔B.V.保留所有权利。
Recent studies demonstrated that an acute psychological stressor elicited transient changes in lymphocyte redistribution. Earlier studies had established that CD3-CD16+CD56+ natural killer cells (NK cells) increased remarkably in peripheral blood circulation and that the amount of lymphocyte redistribution in NK cells was dependent on the CD62L expression density.Specifically, CD62L- cells were mobilized more pronouncedly than were CD62L+ cells. These results led us to hypothesize that such different reactivity causes different temporal characteristics between CD62L+ and CD62L- lymphocyte subsets.The present study was conducted to examine this issue. Ten female participants experienced a 10-minute baseline period and performed a 10-minute mental arithmetic task as an acute psychological stressor. Blood samples for measuring the proportions of CD62L+ or CD62L- NK cells and CD62L+ or CD62L- T cells were obtained immediately after each period and every 2 min during the task. As expected, CD62L+ and CD62L- NK cells showed different reactivity in response to the stressor and showed different temporal characteristics. That is, the elevation of CD62L- NK cells reached a significant level at I min after the initiation of the stressor, while CD62L+ NK cells took 8 min to show a tendency of elevation. Although CD3+ T cells showed different reactivity between CD62L cell types, they did not show different temporal characteristics. These findings suggest that the expression of CD62L modulates not only the amount of redistribution but also the temporal characteristics of the redistribution of NK cells. (C) 2008 Elsevier B.V. All rights reserved.