Effects of chronic ethanol consumption on hepatic metabolism of aromatic and chlorinated hydrocarbons in rats.
Effects of chronic ethanol consumption on hepatic metabolism of aromatic and chlorinated hydrocarbons in rats.
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DOI：
10.1136/oem.37.4.382
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发表时间：
1980-11
期刊：
影响因子：
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通讯作者：
A. Sato;And T NAKAJIMA;Y. Koyama
中科院分区：
文献类型：
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作者：
A. Sato;And T NAKAJIMA;Y. Koyama
在雄性大鼠连续三周每天摄入相当于总能量摄入30%的乙醇后，测量了16种芳香烃或氯化烃的肝脏药物代谢酶的活性。虽然乙醇饲养只使微粒体细胞色素P-450含量略有增加，但它使大多数碳氢化合物的体外代谢增加了3至6倍。这种增强的活性在一天后消失，这表明最近摄入的乙醇在加速碳氢化合物的代谢中起着重要作用。发现乙醇增强的酶活性与发生在微粒体部分而不是可溶性部分的变化有关。一项以甲苯为模型底物的代谢研究表明，长期消耗乙醇会增加大鼠体内这种碳氢化合物的代谢。
The activities of liver drug-metabolising enzymes for 16 aromatic or chlorinated hydrocarbons were measured in male rats after a three-week daily intake of ethanol amounting to 30% of total energy intake. Although the ethanol feeding produced only a slight increase in the microsomal cytochrome P-450 content, it increased the in-vitro metabolism of most hydrocarbons three-to six-fold. That a major part of this enhanced activity disappeared after one-day withdrawal of ethanol suggests that recent intake of ethanol plays an important part in accelerating the metabolism of hydrocarbons. The enzyme activity enhanced by ethanol was found to be related with changes occurring not in the soluble but in the microsomal fractions. A metabolism study using toluene as a model substrate indicated that chronic ethanol consumption increases the in-vivo metabolism of this hydrocarbon in rats.