Increased epicardial adipose tissue volume in HIV-infected men and relationships to body composition and metabolic parameters
Increased epicardial adipose tissue volume in HIV-infected men and relationships to body composition and metabolic parameters
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DOI：
10.1097/qad.0b013e32833c055a
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发表时间：
2010-08-24
期刊：
影响因子：
3.8
通讯作者：
Grinspoon, Steven K.
中科院分区：
文献类型：
--
作者：
Lo, Janet;Abbara, Suhny;Grinspoon, Steven K.
心外膜脂肪堆积可能具有重要的临床后果，但对HIV患者的这种储存库知之甚少。我们比较了78名HIV感染者和32名HIV阴性对照者的心外膜脂肪体积。HIV感染者的心外膜脂肪体积高于对照组（P = 0.04）。在HIV患者中，心外膜脂肪体积与内脏脂肪组织面积（rho = 0.76，P < 0.0001）、空腹血糖（rho = 0.41，P = 0.001）和胰岛素（rho = 0.44，P = 0.0003）密切相关。在控制了年龄、种族、BMI、脂联素、内脏脂肪组织和抗逆转录病毒治疗的情况下，血糖和胰岛素的相关性仍然显著。心外膜脂肪可能是HIV感染患者的重要脂肪储存库。
Epicardial fat accumulation may have important clinical consequences, yet little is known regarding this depot in HIV patients. We compared epicardial fat volume in 78 HIV-infected men and 32 HIV-negative controls. Epicardial fat volume was higher in HIV-infected patients than that in controls (P = 0.04). In HIV patients, epicardial fat volume was strongly associated with visceral adipose tissue area (rho = 0.76, P < 0.0001), fasting glucose (rho = 0.41, P = 0.001) and insulin (rho = 0.44, P = 0.0003). Relationships with glucose and insulin remained significant controlling for age, race, BMI, adiponectin, visceral adipose tissue and antiretroviral therapy. Epicardial fat may be an important fat depot in HIV-infected patients.