Live attenuated influenza vaccine is safe and immunogenic in Immunocompromised ferrets
Live attenuated influenza vaccine is safe and immunogenic in Immunocompromised ferrets
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DOI：
10.1086/500247
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发表时间：
2006-03-01
影响因子：
6.4
通讯作者：
McCullers, JA
中科院分区：
文献类型：
--
作者：
Huber, VC;McCullers, JA
接受癌症化疗的病人极易感染流感病毒。由于对三价灭活流感疫苗（TIV）的反应不理想，在免疫功能低下的宿主中预防流感病毒感染变得复杂。一种新的流感减毒活疫苗（LAIV; FluMist）可能提供一种比TIV更有效的替代方案，但必须首先确定这种LAIV在免疫功能低下患者中的安全性。在目前的研究中，fluumist被用于用地塞米松和阿糖胞苷治疗免疫功能低下的雪貂。雪貂没有表现出可归因于fluumist的体征或症状，免疫功能低下的雪貂对LAIV毒株的鼻腔清除率与对照雪貂相似。对接种菌株的血清抗体反应进行分析，作为疫苗效力的衡量标准。通过微量中和试验评估，免疫功能低下的雪貂对所有3种疫苗株的抗体滴度与模拟处理的对照雪貂相似。这些发现支持这种疫苗在免疫功能低下人群中的潜在应用。
Patients undergoing chemotherapy for cancer are highly susceptible to influenza virus infection. Prevention of influenza virus infection is complicated in the immunocompromised host because of suboptimal responses to the trivalent inactivated influenza vaccine (TIV). A new, live attenuated influenza vaccine (LAIV; FluMist) may offer a more effective alternative to TIV, but the safety of this LAIV in immunocompromised patients must first be established. In the present study, FluMist was administered to ferrets immunocompromised by treatment with dexamethasone and cytarabine. Ferrets exhibited no signs or symptoms attributable to FluMist, and nasal clearance of LAIV strains from immunocompromised ferrets was similar to that from control ferrets. Serum antibody responses against the vaccinating strains were analyzed as a measure of vaccine efficacy. Antibody titers to all 3 vaccine strains in immunocompromised ferrets were similar to those seen in mocktreated control ferrets, as assessed by microneutralization assay. These findings support the potential use of this vaccine in immunocompromised humans.