The role of MACF1 in nervous system development and maintenance.
The role of MACF1 in nervous system development and maintenance.
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DOI：
10.1016/j.semcdb.2017.05.020
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发表时间：
2017-09
影响因子：
7.3
通讯作者：
Kim WY
中科院分区：
文献类型：
--
作者：
Moffat JJ;Ka M;Jung EM;Smith AL;Kim WY
微管-肌动蛋白交联因子1 (MACF1)，也称为肌动蛋白交联因子7 (ACF7)，对肌动蛋白和微管细胞骨架网络的适当调节至关重要。大多数MACF1亚型在体内广泛表达，但有些只在神经系统中发现。因此，MACF1在发育和成年期间全面参与多种神经过程，包括神经突生长和神经元迁移。此外，MACF1参与多种信号通路，包括Wnt/β-catenin和GSK-3信号通路，这些信号通路调节关键的细胞过程，如增殖和细胞迁移。MACF1基因的基因突变或失调与神经发育和神经退行性疾病有关，特别是精神分裂症和帕金森病。MACF1也可能在神经肌肉疾病中发挥作用，并在视神经中具有神经保护作用。在这篇综述中，作者试图综合有关MACF1在神经系统中的作用的最新发现，并探索尚未研究的MACF1的潜在新功能。
Microtubule-actin crosslinking factor 1 (MACF1), also known as actin crosslinking factor 7 (ACF7), is essential for proper modulation of actin and microtubule cytoskeletal networks. Most MACF1 isoforms are expressed broadly in the body, but some are exclusively found in the nervous system. Consequentially, MACF1 is integrally involved in multiple neural processes during development and in adulthood, including neurite outgrowth and neuronal migration. Furthermore, MACF1 participates in several signaling pathways, including the Wnt/β-catenin and GSK-3 signaling pathways, which regulate key cellular processes, such as proliferation and cell migration. Genetic mutation or dysregulation of the MACF1 gene has been associated with neurodevelopmental and neurodegenerative diseases, specifically schizophrenia and Parkinson’s disease. MACF1 may also play a part in neuromuscular disorders and have a neuroprotective role in the optic nerve. In this review, the authors seek to synthesize recent findings relating to the roles of MACF1 within the nervous system and explore potential novel functions of MACF1 not yet examined.
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