Antioxidant vitamins reduce acute meal-induced memory deficits in adults with type 2 diabetes
Antioxidant vitamins reduce acute meal-induced memory deficits in adults with type 2 diabetes
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DOI：
10.1016/j.nutres.2008.03.016
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发表时间：
2008-07-01
影响因子：
4.5
通讯作者：
Greenwood, Carol E.
中科院分区：
文献类型：
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作者：
Chui, Michael Herman;Greenwood, Carol E.
患有 2 型糖尿病 (T2DM) 的成人会出现记忆障碍，进餐后还会出现进一步的急性缺陷。这项研究探讨了餐后氧化应激是否是导致这些膳食引起的记忆缺陷的一个因素。 16 名不定期服用高剂量抗氧化剂补充剂的 T2DM 成年人（平均年龄，63.5 +/- +/- 2.1 岁）被喂食高脂肪膳食、含有维生素 C（1000 毫克）和 E（800 IU）片剂的同一测试餐，或分 3 次喝水。进餐后，进行了一系列认知测试，其中包括延迟言语记忆的测量，在进餐后 60 和 105 分钟进行评估。相对于水的消耗量，高脂肪膳食导致在延迟言语回忆（单词列表和段落回忆）和工作记忆（数字跨度向前）测量方面在摄入后 105 分钟时表现较差。抗氧化维生素和高脂肪膳食的共同消耗可以防止这种膳食引起的缺陷，从而使这些任务的表现与摄入水后的表现没有区别。与此同时，无论是否摄入抗氧化剂，在摄入膳食后，Stroop 的单词命名和颜色命名成分相对于水都有微小但显着的改善，这证明了膳食引起的记忆功能损伤的特异性。通过 Trails A 和 B 部分评估的执行功能不受膳食或抗氧化剂摄入的影响。在患有 T2DM 的成年人中，同时摄入抗氧化维生素可以最大限度地减少膳食引起的记忆障碍，这表明氧化应激是导致记忆力减退的潜在因素。 (c) 2008 Elsevier Inc. 保留所有权利。
Memory impairment is observed in adults with type 2 diabetes mellitus (T2DM), with further acute deficits after meal ingestion. This study explored whether postprandial oxidative stress was a contributor to these meal-induced memory deficits. Sixteen adults with T2DM (mean age, 63.5 +/-+/- 2.1 years) who were not regularly taking high-dose antioxidant supplements were fed a high-fat meal, the same test meal with vitamins C (1000 mg) and E (800 IU) tablets, or water on 3 separate occasions. After meal ingestion, a battery of cognitive tests were administered, which included measures of delayed verbal memory, assessed at 60 and 105 minutes after meal ingestion. Relative to water consumption, the high-fat meal resulted in poorer performance at 105 minutes postingestion on measures of delayed verbal recall (word list and paragraph recall) and working memory (Digit-Span Forward). Coconsumption of antioxidant vitamins and high-fat meal prevented this meal-induced deficit such that performance on these tasks was indistinguishable from that after water intake. At the same time point, a small but significant improvement on the word-naming and color-naming components of Stroop was observed after meal ingestion, relative to water, irrespective of whether antioxidants were consumed, demonstrating the specificity of meal-induced impairments to memory function. Executive function, assessed by Trails Parts A and B, was not influenced by meal or antioxidant ingestion. In adults with T2DM, coconsumption of antioxidant vitamins minimizes meal-induced memory impairment, implicating oxidative stress as a potential contributor to these decrements. (c) 2008 Elsevier Inc. All rights reserved.